Evidence map›Paper›PMID 42426839›Full record

ArticleBMC research notes2026

Antibacterial and wound healing activities of AgNPs, ZnONPs, and Fe

Mohammad Hossein Soleimani, Pegah Shakib, Mohammad Reza Zolfaghari, Ashkan Dirbaziyan, Reza Heidari, Mohsen Chamanara, Saeed Khoshnood, Faeze Fallahi

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Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mohammad Hossein SoleimaniDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Islamic Republic of Iran.
Pegah ShakibRazi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mohammad Reza ZolfaghariDepartment of Microbiology, Qom Branch, Islamic Azad University, Qom, Islamic Republic of Iran. mreza.zolfaghary@gmail.com.
Ashkan DirbaziyanDepartment of Microbiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran.
Reza HeidariCancer Epidemiology Research Center, Aja University of Medical, Tehran, Iran.
Mohsen ChamanaraStudent research committee, Aja University of Medical Sciences, Tehran, Iran.
Saeed KhoshnoodClinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Faeze FallahiCellular and molecular biraniology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to evaluate the individual and combined effects of silver nanoparticles (AgNPs), zinc oxide nanoparticles (ZnO-NPs), and iron oxide nanoparticles (Fe₃O₄-NPs) on wound healing in a rat model of infection with Acinetobacter baumannii and Escherichia coli, and to compare their efficacy with a standard antibiotic treatment.

resultsAgNPs demonstrated the strongest antibacterial growth inhibition in vitro, while ZnO-NPs showed limited antibacterial activity under the tested conditions. Combination assays indicated enhanced bacterial growth inhibition for AgNP + Fe₃O₄-NPs, whereas ZnO-NPs did not increase antibacterial inhibition in vitro. Nanoparticle-treated wounds showed faster healing than controls in rat models infected with E. coli and A. baumannii. Complete wound closure by day nine was observed in the Ag + ZnO and Fe₃O₄ groups for E. coli infection and in the Ag, ZnO, and Ag + ZnO groups for A. baumannii. Wound-healing rates reached 100% in the Fe₃O₄ and Ag + ZnO groups, which was significantly higher than in untreated controls. Histological evaluation revealed no necrosis in any group, while treated wounds exhibited increased granulation tissue formation and reduced inflammation. Overall, the Ag + ZnO nanoparticle combination showed a synergistic effect, leading to superior antibacterial activity and accelerated wound repair.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsEscherichia coliMetal NanoparticlesSilverWound HealingZinc OxideAnimalsEscherichia coli InfectionsMaleMicrobial Sensitivity TestsRatsAnti-Bacterial AgentsSilverZinc OxideAcinetobacter baumanniiEscherichia coliInfected woundIron oxide nanoparticlesSilver nanoparticlesZinc oxide nanoparticles

Identifiers

PMID42426839
PMCPMC13386800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.