Evidence map›Paper›PMID 42426821›Full record

ArticleBiomarker research2026

Molecular PET imaging of integrin αvβ6 reveals biliary and fibrotic changes in preclinical MASH.

Xiaoyi Wang, Mengqi Wang, Pengzhe Han, Huanhuan Song, Xuchen Zhao, Nannan Chen, Congzhong Hu, Xueqin Liu, Xiaolong Li, Xifeng Fu and 4 more

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In one paragraph

Article in Biomarker research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Xiaoyi Wang *The First Affiliated Hospital, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Biomedical Basic Research Center (BBRC) of Jiangsu, Soochow University, Suzhou, Jiangsu, 215123, China.
Mengqi Wang *The First Affiliated Hospital, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Biomedical Basic Research Center (BBRC) of Jiangsu, Soochow University, Suzhou, Jiangsu, 215123, China.
Pengzhe Han *The First Affiliated Hospital, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Biomedical Basic Research Center (BBRC) of Jiangsu, Soochow University, Suzhou, Jiangsu, 215123, China.
Huanhuan SongThe First Affiliated Hospital, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Biomedical Basic Research Center (BBRC) of Jiangsu, Soochow University, Suzhou, Jiangsu, 215123, China.
Xuchen ZhaoDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, China.
Nannan ChenThe First Affiliated Hospital, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Biomedical Basic Research Center (BBRC) of Jiangsu, Soochow University, Suzhou, Jiangsu, 215123, China.
Congzhong HuDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, China.
Xueqin LiuThe First Affiliated Hospital, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Biomedical Basic Research Center (BBRC) of Jiangsu, Soochow University, Suzhou, Jiangsu, 215123, China.
Xiaolong LiDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, China.
Xifeng FuDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, China.
Steven LiangDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Zhifang WuDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030001, China. wuzhifang01@163.com.
Yanzhang TianDepartment of Biliary and Pancreatic Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, China. tyz2030@163.com.
Tuo ShaoThe First Affiliated Hospital, The Institutes of Biology and Medical Sciences, Suzhou Medical College, Biomedical Basic Research Center (BBRC) of Jiangsu, Soochow University, Suzhou, Jiangsu, 215123, China. shaotuo@suda.edu.cn.ORCID https://orcid.org/0000-0001-7144-9823

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe progression of metabolic dysfunction-associated steatohepatitis (MASH) involves complex crosstalk among hepatocellular injury, inflammation, and ductular reaction-a process characterized by biliary epithelial proliferation and fibrotic activation. Integrin αvβ6, an epithelial-specific receptor largely absent in normal liver but induced under chronic injury, plays a pivotal role in activating latent TGF-β and driving fibrogenesis. Here, we investigated αvβ6 as a molecular imaging biomarker in MASH using a PET-based strategy to non-invasively visualize epithelial fibrotic signaling in vivo.

methodsPET/CT imaging and autoradiography studies were performed in MASH mice at different disease stages using [

resultsIn both CDAHFD and MCDD models, hepatic [

conclusionsThis study identifies integrin αvβ6-targeted PET as a potential molecular imaging strategy to map epithelial remodeling in MASH. Ex vivo analyses of human MASH specimens support the translational relevance of this target, although prospective clinical PET studies and longitudinal outcome validation are required before clinical diagnostic application.

Indexed as

Biliary epithelial cellsDiagnosisIntegrin αvβ6Liver fibrosisMASHPET imaging

Identifiers

PMID42426821
PMCPMC13536694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.