ArticleBMC geriatrics2026
Immune-inflammatory and nutritional status mediate the association between age and survival in older patients with nasopharyngeal carcinoma: a retrospective cohort study.
Article in BMC geriatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Comparative effects of aerobic exercise in early versus late middle age on skeletal muscle function and miRNA profiling in mice.Molecular biology reports · 2026Article
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10 authors.
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Abstract
backgroundImmune-inflammatory and nutritional status are recognized as influencing factors for survival in older patients with nasopharyngeal carcinoma (NPC). This study explores the relationships between age, immune-inflammatory and nutritional status and survival outcomes, and the potential mediating effect in this association.
methodsWe analyzed 977 non-metastatic NPC patients aged ≥ 60 years between January 2015 and December 2022. Overall survival (OS) and cancer-specific survival (CSS) served as the primary endpoints. Mediation analyses were performed to assess the effects of age and immune-inflammatory and nutritional status on the prognosis. Restricted cubic spline curves were employed to investigate non-linear associations. Kaplan-Meier analysis was used to analyze the survival endpoints.
resultsAge independently predicted poorer survival, with platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI) and serum albumin (ALB) emerging as significant prognostic factors in older NPC patients. Mediation analysis revealed that the indirect effects of age on OS through PLR, PNI, and ALB were 0.01%, 3.7%, and 6.2%, respectively, and the indirect effects on CSS were - 0.01%, 6.7%, and 7.7%, respectively. Among them, ALB values significantly mediated the effects of age on OS and CSS (both P_indir < 0.01), persisting after multivariable adjustment. Patients with ALB values ≥ 41.3 g/L exhibited superior 5-year OS (77.5% vs. 66.7%, P < 0.001) and CSS (80.6% vs. 71.3%, P < 0.001), with subgroup analyses confirming robustness.
conclusionsImmune-inflammatory and nutritional status mediate age-dependent survival disparities in older NPC patients. These findings underscore the clinical imperative of addressing inflammatory burden and nutritional depletion in geriatric oncology and advocate for integrated biomarker-guided management strategies.
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