Evidence map›Paper›PMID 42426606›Full record

ArticleBMC microbiology2026

Insight into the molecular characteristics of community-associated Staphylococcus aureus isolates from pediatric patients in South China.

Huamiao Tang, Cong Li, Yun Zhou, Xiangmin Zhou, Keni Jian, Xing Wang

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Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Huamiao Tang *Department of Laboratory Medicine, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, 572000, China.
Cong Li *Department of General Internal Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yun Zhou *Department of Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Xiangmin ZhouDepartment of Laboratory Medicine, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, 572000, China.
Keni JianDepartment of Laboratory Medicine, Hainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Sanya, 572000, China.
Xing WangDepartment of Laboratory Medicine, Shanghai Children's Medical Center, School of Medicine, National Children's Medical Center, Shanghai Jiaotong University, Shanghai, 200127, China. wx_5166@163.com.

Funding

the JINYE ZHONGZI Project from the Hainan Branch of Shanghai Children's Medical Center No. JYZZ-QN-01
6 · The paper itself

Abstract

backgroundCommunity-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) poses a significant global public health threat. However, data on community-associated S. aureus (CA-SA) infections in children in Hainan remain scarce. This study aimed to characterize the molecular characteristics of CA-SA isolates obtained from pediatric patients at a university hospital in Hainan, the southernmost province of China.

methodsA total of 117 CA-SA isolates, including 31 MRSA and 86 methicillin-susceptible S. aureus (MSSA), were collected in Hainan between July 2023 and May 2025. These isolates were characterized using multilocus sequence typing (MLST), staphylococcal protein A (spa) typing, staphylococcal cassette chromosome mec (SCCmec) typing, and analyses of antimicrobial resistance and virulence gene profiles.

resultsEighteen distinct sequence types (STs) and 49 spa types were identified among the 117 isolates, with ST398-t011(15,12.8%) and ST22-t039(15,12.8%) being the most prevalent. ST398 and ST22 were the dominant clones among MSSA isolates, whereas ST59-SCCmec IV/V(10, 8.5%) and ST45-SCCmec IV(9,7.7%) were the predominant clones among MRSA isolates. The prevalence of CA-MRSA was 26.5%, with SCCmec types IV and V accounting for 71% and 29% of cases, respectively. All isolates exhibited susceptibility to tigecycline, teicoplanin, linezolid, and vancomycin, while 69 isolates (59.0%) were classified as multidrug-resistant (MDR). Compared to CA-MSSA strains, CA-MRSA isolates demonstrated significantly higher resistance rates to cefoxitin, oxacillin, erythromycin, clindamycin, and levofloxacin. The predominant resistance genes for erythromycin and tetracycline were ermC (77.2%, 51/66) and tetK (82.4%, 28/34), respectively. Among the 32 virulence genes tested, hla, hld, icaA, and clfA were detected in all isolates, whereas lukM was absent in all. The seb, sel, sek, and seq genes were more frequently identified in CA-MRSA isolates, while sdrD and lukE were more commonly detected in CA-MSSA isolates.

conclusionsThis study represents the first report on the molecular characteristics of CA-SA strains isolated from pediatric populations in Hainan, identifying ST398, ST22, ST59, and ST45 as the predominant genotypes. Notably, CA-MRSA epidemic strains in this region exhibit substantial molecular heterogeneity, reflecting distinct regional epidemiological patterns. These findings provide updated insights into the molecular epidemiology of S. aureus strains, offering critical reference data for clinical management and infection prevention strategies in pediatric settings.

Indexed as

Community-Acquired InfectionsMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsBacterial ProteinsChildChild, PreschoolChinaDrug Resistance, Multiple, BacterialFemaleHumansInfantMaleMicrobial Sensitivity TestsMultilocus Sequence TypingAnti-Bacterial AgentsBacterial ProteinsStaphylococcal Protein AVirulence FactorsAntimicrobial resistanceCommunity-associated Staphylococcus aureusMolecular characteristicPediatricVirulence gene

Identifiers

PMID42426606
PMCPMC13492025

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