ArticleBMC genomics2026
Integrated transcriptomic and metabolomic analysis revealed the potential role of hesperetin in wheat resistance to leaf rust.
Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNatural plant metabolites, such as flavonoids and lignin, exhibited safe and environmentally friendly roles in defending against pathogen attack. However, their functional roles in the interaction between wheat and Puccinia triticina (Pt) remained poorly characterized.
resultsIn this study, we integrated transcriptomic and quasi-targeted metabolomic analyses to systematically characterize differentially expressed genes (DEGs) and metabolites associated with the compatible and incompatible interactions between wheat and Pt. In the wheat-Pt interaction system, a total of 1,242 metabolites were identified, predominantly classified into amino acids and derivatives, flavonoids, and related compound classes. In the flavonoid and lignin biosynthesis-related pathways-namely, Flavonoid biosynthesis and Phenylpropanoid biosynthesis-significant differences were observed in both the accumulation levels of key metabolites and the expression of genes associated with their biosynthetic pathways. Notably, in the incompatible interaction, the expression of TaCAD, a gene implicated in syringyl lignin (S-lignin) biosynthesis, was significantly up-regulated. Gene regulatory network (GRN) analysis further suggested that transcription factors (TFs) including ERF, LBD, BBR-BPC, and C
conclusionsThese findings indicated that hesperetin may serve as a potential defense compound in wheat during the early stages of leaf rust infection, providing crucial insights for developing novel natural products and a theoretical foundation for genetic improvement in disease-resistant wheat breeding.
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