Evidence map›Paper›PMID 42426537›Full record

ArticlePituitary2026

Endoscopic endonasal infrachiasmatic approach to intra-third ventricle craniopharyngiomas: surgical outcomes and limits to complete resection.

Rayford Hazunga, Hiroki Morisako, Atsufumi Nagahama, Masaki Ikegami, Boon Seng Liew, Takeo Goto

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Article in Pituitary, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Rayford HazungaDepartment of Neurosurgery, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Hiroki MorisakoDepartment of Neurosurgery, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan. hmorisako@omu.ac.jp.
Atsufumi NagahamaDepartment of Neurosurgery, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Masaki IkegamiDepartment of Neurosurgery, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Boon Seng LiewDepartment of Neurosurgery, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.
Takeo GotoDepartment of Neurosurgery, Graduate School of Medicine, Osaka Metropolitan University, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the surgical outcomes of the endoscopic endonasal infrachiasmatic approach (EEIA) for intra-third ventricle craniopharyngiomas (IVC) and to define the anatomical limits of tumor resection through this corridor.

methodsWe retrospectively analyzed 21 cases of IVCs (17 primary and 4 recurrent) who underwent EEIA between 2016 and 2025. Clinical data were obtained from the institution's database. Surgical outcomes and anatomical limits of tumor resection were examined.

resultsGross total resection (GTR) was achieved in 18 cases and subtotal resection (STR) in 3 cases. Among patients with preoperative visual and cognitive impairment, improvements were noted in 69.2% and 88.9%, respectively. Tumor margins extending beyond the anterior suprachiasmatic limit of visualization of the infrachiasmatic corridor (IC), corresponding to the chiasma-clival line (CCL), limited safe dissection. Furthermore, tumor adherence to adjacent vasculature and mammillary bodies represented an additional limitation.

conclusionThe EEIA may enable aggressive resection of IVCs while preserving and improving visual and cognitive function. Complete resection is limited by the geometry of the operative corridor and tumor adherence to vital structures. The CCL may serve as a practical marker of the anterior suprachiasmatic limit of the corridor and aid in preoperative planning, particularly in identifying cases that may require alternative or staged approaches.

Indexed as

CraniopharyngiomaPituitary NeoplasmsThird VentricleAdolescentAdultFemaleHumansMaleMiddle AgedNeuroendoscopyRetrospective StudiesTreatment OutcomeYoung AdultCraniopharyngiomaEndoscopic endonasal approachExtent of resectionInfrachiasmatic approachSurgical outcomesThird ventricle

Identifiers

PMID42426537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.