Evidence map›Paper›PMID 42426470›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2026

New Strategies to Uncover Genes Involved in the Development of Prostate Cancer in Families with Multiple Cases.

Lucía Chica-Redecillas, Beatriz Álvarez-González, Sergio Cuenca-López, Maria Jesus Alvarez-Cubero, Luis Javier Martínez-González

Abstract readReview
PubMed Publisher
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucía Chica-RedecillasDepartment of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Health Sciences Technology Park (PTS), Granada, Spain.
Beatriz Álvarez-GonzálezGENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Spain.
Sergio Cuenca-LópezGENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Health Sciences Technology Park (PTS), Granada, Spain.
Maria Jesus Alvarez-CuberoDepartment of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Health Sciences Technology Park (PTS), Granada, Spain. mjesusac@ugr.es.
Luis Javier Martínez-GonzálezDepartment of Biochemistry and Molecular Biology III and Immunology, Faculty of Medicine, University of Granada, Health Sciences Technology Park (PTS), Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer (PC) is the fourth most common cancer worldwide and is recognised as one of the major men's health challenges of the twenty-first century. There has been a steady increase in PC incidence, particularly for advanced-stage PC cases, which have increased by 5% since 2014. Despite advances in diagnostic and treatment techniques, understanding of the genetic mechanisms underlying PC remains limited, especially in families with multiple cases of the disease, where genetic predispositions significantly increase the risk of developing cancer. This chapter provides a comprehensive and up-to-date review of PC, covering key aspects such as its epidemiology, aetiology and associated risk factors. From the hereditary point of view, this chapter covers the main genes associated with the susceptibility to develop PC and related pathologies. Additionally, the chapter evaluates the current paradigm of detection and treatment protocols, while also exploring future research directions.

Indexed as

Genetic Predisposition to DiseaseProstatic NeoplasmsHumansMaleRisk FactorsCancer developmentFamilial cancerGeneticsProstate cancerRisk factors

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.