Evidence map›Paper›PMID 42426395›Full record

ArticleSurgical endoscopy2026

Comparing venous thromboembolism (VTE) prophylaxis and bleeding risks: low molecular weight heparin vs. unfractionated heparin in open repairs of large hernias.

Huzaifa Razzaq, Tariq Saleh, Rana M Higgins, Kathleen Lak, Andrew Kastenmeier, Matthew I Goldblatt, Wen Hui Tan

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huzaifa RazzaqDivision of Minimally Invasive and Gastrointestinal Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd. HUB, 6Th Floor, Milwaukee, WI, 53226, USA.
Tariq SalehDivision of Minimally Invasive and Gastrointestinal Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd. HUB, 6Th Floor, Milwaukee, WI, 53226, USA.
Rana M HigginsDivision of Minimally Invasive and Gastrointestinal Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd. HUB, 6Th Floor, Milwaukee, WI, 53226, USA.
Kathleen LakDivision of Minimally Invasive and Gastrointestinal Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd. HUB, 6Th Floor, Milwaukee, WI, 53226, USA.
Andrew KastenmeierDivision of Minimally Invasive and Gastrointestinal Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd. HUB, 6Th Floor, Milwaukee, WI, 53226, USA.
Matthew I GoldblattDivision of Minimally Invasive and Gastrointestinal Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd. HUB, 6Th Floor, Milwaukee, WI, 53226, USA.
Wen Hui TanDivision of Minimally Invasive and Gastrointestinal Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd. HUB, 6Th Floor, Milwaukee, WI, 53226, USA. whtan@mcw.edu.ORCID http://orcid.org/0000-0001-9486-9652

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVenous thromboembolism (VTE) remains a major cause of postoperative morbidity and mortality in surgical patients undergoing open large abdominal wall hernia repairs. Uncertainty persists about whether low molecular weight heparin (LMWH) or unfractionated heparin (UFH) provides superior protection against VTEs without increasing bleeding risk. We sought to compare efficacy.

methodsWe conducted a retrospective cohort study of adults undergoing open large abdominal wall hernia repairs at a single institution from 2019 to 2025. Patients received either LMWH or UFH for VTE prophylaxis. The primary endpoint was VTE within 30 days of surgery. Secondary endpoints included bleeding complications (hematomas, transfusion requirements, and reoperations for bleeding). Multivariable logistic regression was performed to assess independent risk factors for VTE and bleeding complications.

resultsA total of 309 patients were included in this study: 156 patients received LMWH and 153 patients received UFH for VTE prophylaxis. The mean patient age was 59.0 ± 12.6 years, mean BMI was 34.5 ± 7.7 kg/m2, and median hernia area was 150 cm

conclusionsIn patients undergoing open large abdominal wall hernia repairs, LMWH and UFH demonstrated similar rates of VTEs and bleeding complications. These findings suggest that either agent is reasonable for prophylaxis in this population, and selection may be guided by patient-specific factors or institutional protocols.

Indexed as

AnticoagulantsHeparinHeparin, Low-Molecular-WeightHerniorrhaphyPostoperative ComplicationsPostoperative HemorrhageVenous ThromboembolismAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsAnticoagulantsHeparinHeparin, Low-Molecular-WeightHerniaLow molecular weight heparinOpen hernia repairPostoperative bleedingUnfractionated heparinVenous thromboembolism

Identifiers

PMID42426395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.