ArticleNpj mental health research2026
Personality changes following first-time psychedelic use in college students in Germany.
Article in Npj mental health research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychedelics may influence personality traits, but longitudinal evidence on first-time use outside clinical settings remains limited. We followed 102 first-time psychedelic users and 1066 never-users over one year among Berlin university students. Personality was assessed with the Big Five Inventory at baseline and follow-up. Linear mixed-effects models showed small relative increases in Openness and decreases in Conscientiousness among first-time users. After adjustment for age, sex, income, psychiatric diagnosis, and baseline substance-use burden, estimates were attenuated but directionally similar (Openness: beta = 0.19, SE = 0.10, p = 0.06; Conscientiousness: beta = -0.20, SE = 0.10, p = 0.05; FDR-adjusted p = 0.16 for both). Change was not clearly different from first-time users of other illicit substances. In exploratory moderation analyses, first-time users with psychiatric diagnoses showed larger Neuroticism reductions. Findings suggest small personality changes after first-time psychedelic use, with limited causal interpretability.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.