Evidence map›Paper›PMID 42426339›Full record

ArticleGeroScience2026

Frailty and incident cognitive impairment in patients with CKD: sex-frailty paradox in the Chronic Renal Insufficiency Cohort (CRIC).

Stephanie Lapierre-Nguyen, Zhiying You, Michel Chonchol, Kristen L Nowak, Ester Oh

Abstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephanie Lapierre-NguyenDivision of Renal Diseases and Hypertension, University of Colorado Anschutz, Aurora, CO, USA.ORCID http://orcid.org/0000-0003-3539-0427
Zhiying YouDivision of Renal Diseases and Hypertension, University of Colorado Anschutz, Aurora, CO, USA.
Michel ChoncholDivision of Renal Diseases and Hypertension, University of Colorado Anschutz, Aurora, CO, USA.
Kristen L NowakDivision of Renal Diseases and Hypertension, University of Colorado Anschutz, Aurora, CO, USA.
Ester OhDivision of Renal Diseases and Hypertension, University of Colorado Anschutz, Aurora, CO, USA. ester.oh@cuanschutz.edu.ORCID http://orcid.org/0000-0003-4942-0762

Funding

Inspiratory muscle strength training for lowering systolic blood pressure in midlife and older adults with chronic kidney diseaseR01DK130266 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CHONCHOL, MICHEL BENJAMIN, NOWAK, KRISTEN LYNN · 2021 to 2025
$2.8M
American Heart Association 24CDA1274418NHLBI NIH HHS 1K01HL179491NIDDK NIH HHS R01DK130266
6 · The paper itself

Abstract

Frailty is associated with incident cognitive impairment in patients receiving hemodialysis; however, this association in patients with non-dialysis CKD remains unknown. In addition, recent evidence points to a sex-frailty paradox in cognitive impairment, a phenomenon that has not yet been examined in non-dialysis CKD. We aimed to evaluate the association between frailty and incident cognitive impairment in the Chronic Renal Insufficiency Cohort study participants and to explore whether this association differs by sex. The predictor was baseline frailty and the outcome was incident cognitive impairment (defined as a decline in the Modified Mini-Mental State Examination [3MS] score by more than 1 standard deviation below the cohort mean). Cox proportional hazards models were used to examine the association between frailty and cognitive impairment in the entire cohort and stratified by sex. A total of 1,370 patients (41% women; 64 ± 9 years; baseline eGFR of 59 ± 13 mL/min/1.73 m

Indexed as

Chronic kidney diseaseCognitive impairmentFrailtySex differences

Identifiers

PMID42426339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.