Evidence map›Paper›PMID 42426274›Full record

ArticleEye (London, England)2026

Associations between cataract and cognitive impairment in a sample of the United States Population.

Chris Zajner, Ryan S Huang, Marko M Popovic, Peter J Kertes, Rajeev H Muni, Radha P Kohly

Abstract read
In one paragraph

Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chris ZajnerSchulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.ORCID http://orcid.org/0000-0002-0204-6497
Ryan S HuangTemerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-3404-5376
Marko M PopovicDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0370-5968
Peter J KertesDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-0348-5096
Rajeev H MuniDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada.
Radha P KohlyDepartment of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada. radha.kohly@utoronto.ca.ORCID http://orcid.org/0000-0002-1355-6599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectiveVisual impairment has recently been identified as a key modifiable risk factor for dementia. This study investigates the associations between cognitive impairment with both cataract diagnosis and sociodemographic determinants in a large representative sample of the United States civilian, noninstitutionalised population. SUBJECTS/

methodsThis is a Cross-sectional study using data from the 2023 iteration of the National Health Interview Survey (NHIS). Participants of the NHIS were included if they answered key questions regarding cognitive impairment and cataract. The primary outcomes included the associations between cognitive impairment with cataract, controlling for sociodemographic factors and modifiable risk factors for dementia. Associations were modelled through univariable and multivariable logistic regression analysis.

resultsOverall, 29,522 participants were included in the study, comprising 13,462 males (45.6%) and 16,060 females (54.4%). Of these, 19,781 (67.0%) were under the age of 65, while 9,741 (33.0%) were 65 or older. Univariable analysis showed that there were higher odds of cognitive impairment amongst those with cataract (OR = 2.31, p < 0.001). Multivariable analysis showed significant associations between cognitive impairment with cataract (OR = 1.58, p < 0.001), high cholesterol (OR = 1.49, p = 0.004), depression (OR = 2.75, p < 0.001), history of traumatic brain injury (OR = 1.52, p < 0.001), smoking (OR = 1.16, p < 0.025), social isolation (OR = 4.11, p < 0.001), low levels of physical activity (OR = 1.69, p < 0.001), and hearing impairment (OR = 2.26, p < 0.001).

conclusionsCognitive impairment was robustly associated with cataract in a representative sample of the United States civilian population age 18 and older. Health policymakers should consider the impact of cataract in designing preventative and treatment strategies for individuals with cognitive impairment.

Indexed as

CataractCognitive DysfunctionAdolescentAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHealth SurveysHumansMaleMiddle AgedPrevalenceRisk FactorsUnited StatesYoung Adult

Identifiers

PMID42426274
PMCPMC13601599

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.