Evidence map›Paper›PMID 42426222›Full record

ArticleNature medicine2026

Challenges and future directions for multiple sclerosis after the 2024 McDonald diagnostic criteria.

Jiwon Oh, Frederik Barkhof, Amit Bar-Or, Olga Ciccarrelli, Timothy Coetzee, Massimo Filippi, Cristina Granziera, Yael Hacohen, Bernhard Hemmer, Orhun H Kantarci and 19 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Jiwon OhDivision of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. jiwon.oh@unityhealth.to.ORCID http://orcid.org/0000-0001-5519-6088
Frederik BarkhofDepartment of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3543-3706
Amit Bar-OrThe Center for Neuroinflammation and Experimental Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7179-0335
Olga CiccarrelliQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.ORCID http://orcid.org/0000-0001-7485-1367
Timothy CoetzeeNational Multiple Sclerosis Society, New York, NY, USA.
Massimo FilippiVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0002-5485-0479
Cristina GranzieraDepartment of Neurology, University Hospital and University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-4917-8761
Yael HacohenQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Bernhard HemmerDepartment of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Orhun H KantarciMayo Clinic, Rochester, MN, USA.
Ho Jin KimDepartment of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, South Korea.
Christine Lebrun-FrenayCentre Hospitalier Universitaire Pasteur 2, Service de Neurologie, CRC-SEP, Unitéde Recherche Clinique Côte d'Azur (UR2CA-URRIS), Nice, France.ORCID http://orcid.org/0000-0002-3713-2416
Xavier MontalbanMultiple Sclerosis Centre of Catalonia, Barcelona, Spain.
Ellen MowryDepartment of Neurology, Division of Neuroimmunology and Neurological Infections, Johns Hopkins University, Baltimore, MD, USA.
Daniel OntanedaMellen Center for Multiple Sclerosis, Department of Neurology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Alexandre PratCentre Hospitalier de l'Université de Montréal, Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-6188-0580
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2628-4334
Àlex RoviraSection of Neuroradiology, Department of Radiology (IDI), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
Pascal SatiDepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Aksel SivaDepartment of Neurology, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Andrew J SolomonDepartment of Neurological Sciences, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0003-1602-1554
Maria Pia SormaniDepartment of Health Sciences (DISSAL), Biostatistics Unit, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0001-6892-104X
Bruno StankoffSorbonne University, Paris Brain Institute, INSERM, CNRS, Neurology Department, Pitié Salpetriere Hospital, APHP, Paris, France.
Alan ThompsonQueen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.ORCID http://orcid.org/0000-0002-4333-8496
Mar TintoreMultiple Sclerosis Centre of Catalonia, Barcelona, Spain.ORCID http://orcid.org/0000-0001-9999-5359
Anthony TraboulseeDepartment of Medicine (Neurology), University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-0351-9639
Anneke van der WaltDepartment of Neuroscience, School for Translational Medicine, Monash University and Alfred Health, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-4278-7003
Heinz WiendlDepartment of Neurology and Neurophysiology, University Hospital Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0003-4310-3432
Peter A CalabresiMultiple Sclerosis Centre of Catalonia, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7776-6472

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42426222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.