Evidence map›Paper›PMID 42426171›Full record

ReviewCommunications biology2026

Intestinal muscularis in health and disease.

Wuyan Yang, Jing Yang, Qiman Zou, Haijun Tu

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wuyan YangState Key Laboratory of Chemo and Biosensing, Hunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, 410082, Hunan, China.
Jing YangState Key Laboratory of Chemo and Biosensing, Hunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, 410082, Hunan, China.
Qiman ZouState Key Laboratory of Chemo and Biosensing, Hunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, 410082, Hunan, China.
Haijun TuState Key Laboratory of Chemo and Biosensing, Hunan Research Center of the Basic Discipline for Cell Signaling, College of Biology, Hunan University, Changsha, 410082, Hunan, China. haijuntu@hnu.edu.cn.ORCID 0000-0002-8960-856X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestinal muscularis is a multifunctional tissue that coordinates motility, immune responses, and tissue homeostasis through interactions among enteric neurons, smooth muscle cells (SMCs), and immune cells. Beyond its classical role in peristalsis, emerging evidence identifies the intestinal muscularis as an active regulatory hub integrating neural, immune, and microbial signals. Here, we review the anatomical organization, physiological functions, and pathological alterations in inflammatory bowel diseases, irritable bowel syndrome, infection, and Hirschsprung disease. We further highlight how disruption of integrated neuromuscular and immune networks drives pathological remodeling and discuss emerging concepts and future directions in muscularis biology.

Indexed as

Intestinal DiseasesIntestinesMuscle, SmoothAnimalsHirschsprung DiseaseHumansInflammatory Bowel Diseases

Identifiers

PMID42426171
PMCPMC13350095

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.