Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Ken MatobaDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Takahiro KochiDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Oluwaseun FatobaDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-9046-3943
Md Sorwer Alam ParvezDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-9726-1009
Inssaf BerkiksDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Yassin R MreyoudDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-2747-3652
Harrison StrongDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Jana H BadraniDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0001-6479-7969
Hency PatelDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Yoshiko Nagaoka-KamataDepartment of Pathology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.
Masakazu KamataDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0003-0323-3742
Minae NiwaDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA.ORCID http://orcid.org/0000-0002-8784-7815
Shin-Ichi KanoDepartment of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL, USA. sikano@uabmc.edu.ORCID http://orcid.org/0000-0002-5171-3436
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8M
Thalamic microglia drive cognitive impairment after cortical injuriesR01NS133242 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Shinichi Kano · 2024 to 2026
$1.6M
Influence of thalamic IL-33 signaling in aging-associated exacerbation of cognitive impairment after brain injury via microglial dysfunction and tau pathologyR01AG079129 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Shinichi Kano · 2025 to 2026
$905k
Predoctoral Training in Multifaceted Translational Approach to Mental IllnessT32MH129274 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Yogesh Dwivedi, ADRIENNE C LAHTI · 2023 to 2026
$579k
The Role of Immune Cells within Maternal Immune Activation-Induced Behavioral DeficitsF30MH139313 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BADRANI, JANA HICHAM · 2025 to 2025
$43k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) P30AI027767NCI NIH HHS P30 CA013148NIAID NIH HHS P30 AI027767NIA NIH HHS R01 AG079129NIGMS NIH HHS T32 GM008361NIMH NIH HHS F30 MH139313NIMH NIH HHS T32 MH129274NINDS NIH HHS R01 NS133242U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) T32GM008361U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F30MH139313U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) T32MH129274U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS133242U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG079129U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) P30CA013148
6 · The paper itself
Abstract
Chronic neuroinflammation gives rise to diverse microglial states across the brain, yet how region-specific microglial remodeling contributes to cognitive dysfunction remains unclear. Here we report that synapse-engulfing microglia in the thalamus drive cognitive impairment after cortical brain damage in mice, primarily studied in females. Region-specific manipulations of microglia during the chronic phase show that reactive microglial changes in the thalamus, but not in the hippocampus, impair recognition memory. Single-cell RNA sequencing reveals an enrichment of synapse-engulfing CD9
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
FcγR- and CD9-dependent synapse-engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage in mice. · full record | OpenQuestion