ArticleThe European respiratory journal2026
Aberrant and ectopic cell populations in restrictive allograft syndrome after lung transplantation.
Article in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Aberrant and ectopic cell populations in restrictive allograft syndrome after lung transplantation.The European respiratory journal · 2026Article
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31 authors.
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Abstract
rationaleRestrictive allograft syndrome (RAS) is a major cause of mortality following lung transplantation due to progressive fibrosis of the lung allograft, with no therapeutic options. Knowledge of the cellular and molecular mechanisms driving fibrosis in RAS remains limited.
objectiveTo characterise the cellular and molecular changes in human RAS lungs through single-nucleus transcriptomic profiling.
methodsSingle-nucleus RNA-sequencing (snRNA-seq) was performed in peripheral lung tissues from 15 RAS patients undergoing lung re-transplantation, and from nine healthy control lungs. Findings were validated and extended using histological techniques including immunofluorescence, RNA MEASUREMENTS AND MAIN
resultssnRNA-seq analysis of RAS lungs revealed previously undescribed aberrant basaloid cells, ectopic
conclusionConsidering the multifaceted differences of RAS and idiopathic pulmonary fibrosis, we revealed a surprising general principle of an entity-spanning composition of the fibrotic niche by aberrant basaloid cells localised at the fibrotic edge, ectopic
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