Trial reportOpen heart2026
Effects of early continuous renal replacement therapy in critically ill patients requiring ECMO treatment: results of a randomised controlled trial.
Trial report in Open heart, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03549923 (Impact of Early CRRT Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Early CRRT Intervention in Patients Receiving VA-ECMO Support on 30-day Mortality: A Randomized Controlled Trial
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExtracorporeal membrane oxygenation (ECMO) is increasingly used to treat patients with severe cardiac and pulmonary failure but the complications of acute kidney injury and fluid overload are common. We aimed to determine whether the early initiation of continuous renal replacement therapy (CRRT) can reduce 30-day mortality in patients with ECMO.
methodsThe Evaluation of early CRRT intervention in patients with ECMO study was an investigator-initiated, multicentre, randomised, open clinical trial of patients undergoing ECMO who were randomly assigned to early initiation of CRRT (within 24 hours after ECMO) or conventionally indicated initiation of CRRT. All participants received standard diagnostic and therapeutic procedures. The primary endpoint was the 30-day mortality. A sample size of 500 patients was estimated to provide 80% power and a two-sided α of 0.05 to detect a 20% relative reduction in 30-day mortality assuming a rate of 70% in the usual care group. The primary analysis was unadjusted.
resultsThe study stopped early due to feasibility. Of the 131 patients assessed for eligibility, 40 were excluded based on the inclusion and exclusion criteria. Of the 91 randomised patients, 46 were assigned to the early CRRT group and 45 were assigned to the usual care group. In the intervention group, 35 patients (76.1%) received CRRT within 24 hours post-ECMO implementation vs 15 patients (33.3%) in the usual care group. In the intention-to-treat analysis, the primary outcome occurred in 20 patients (43.5%) in the early CRRT group and 21 patients (46.7%) in the usual care group (HR 0.93, 95% CI 0.50 to 1.72; p=0.75). There was no significant difference in serious adverse events between the two groups (11 (25.6%) vs 9 (21.4%); OR 1.26, 95% CI 0.46 to 3.45; p=0.65).
conclusionsEarly implementation of CRRT in patients with ECMO showed no evidence of a difference in 30-day mortality compared with conventional initiation. However, the trial was substantially underpowered and clinically important benefits or harms cannot be excluded. TRIAL REGISTRATION NUMBER: NCT03549923.
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