Evidence map›Paper›PMID 42425714›Full record

ArticleJournal for immunotherapy of cancer2026

Clinical significance of CD161

Shao-Jun Xu, Chao Chen, Ming-Qiang Ye, Jin Huang, Jia-Hua Tu, Yan-Ming Shen, Yun-Fan Luo, Zhao-Min Sun, Jie Chen, Ji-Hong Lin and 3 more

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shao-Jun Xu *Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Chao Chen *Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Ming-Qiang Ye *Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Jin Huang *Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Jia-Hua TuDepartment of Thoracic Surgery, The First Hospital of Putian, Putian, China.
Yan-Ming ShenDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Yun-Fan LuoDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Zhao-Min SunDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Jie ChenDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Ji-Hong LinDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Jun GuanDepartment of Thoracic Surgery, The First Hospital of Putian, Putian, China.
Han-Xing HuangPathology Department, The First Hospital of Putian City, Putian, China.
Shu Chen ChenDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China cscdoctor@163.com.ORCID http://orcid.org/0000-0002-3316-9908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD161

methodsWe integrated a multicenter cohort of ESCC patients who underwent either surgery or neoadjuvant therapy (chemotherapy or chemoimmunotherapy). Multiplex immunofluorescence staining, survival analyses, and assessment of major pathological response (MPR) and pathological complete response (pCR) were performed to elucidate the clinical relevance of CD161

resultsHigh intratumoral infiltration of CD161

conclusionsWe identify CD161

Indexed as

CD8-Positive T-LymphocytesEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaTumor MicroenvironmentTumor Necrosis Factor Receptor Superfamily, Member 9AgedFemaleHumansMaleMiddle AgedPathologic Complete ResponsePrognosisRadiomicsSignal TransductionTNFRSF9 protein, humanTumor Necrosis Factor Receptor Superfamily, Member 9co-stimulatory moleculesEsophageal Squamous Cell CarcinomaImmunosuppressionTumor Microenvironment

Identifiers

PMID42425714
PMCPMC13358259

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.