ArticleLupus science & medicine2026
Real-world experience with personalised belimumab spacing in sustained SLE remission: a multicentre study.
Article in Lupus science & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the feasibility and safety of belimumab dose spacing and withdrawal in patients with SLE in long-standing remission on belimumab.
methodsPatients with SLE fulfilling the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) criteria who underwent belimumab spacing and/or discontinuation were identified across four tertiary rheumatology centres. The shared belimumab step-down strategy consisted of spacing to subcutaneous (SC) 200 mg/10 days (or intravenous (IV) 10 mg/kg/6 weeks). In the absence of flares, belimumab could be progressively tapered every 6-12 months to SC 200 mg/14 days (or IV 10 mg/kg/8 weeks), SC 200 mg/21 days (or IV 10 mg/kg/12 weeks), SC 200 mg/28 days (or IV 10 mg/kg/16 weeks) and eventually discontinued. PRIMARY ENDPOINT: SLE flares occurrence.
resultsAmong 152 patients with SLE treated with belimumab, 22 (14.5%) underwent spacing for sustained remission (21 females (95.5%), mean±SD age 47±11 years). Spacing patients had longer mean remission duration compared with standard-dose belimumab (67±30 vs 33±32 months, p<0.001), less serological activity (low complement and/or positive anti-double stranded DNA 31.8% vs 54.6%, p=0.048), lower SLE Disease Activity Index 2000 (0.77±1.23 vs 1.98±2.01, p<0.001) and were less often on glucocorticoids (22.7% vs 47.7%, p=0.029) or additional immunosuppressants (0.0% vs 50.8%, p<0.001). During the 21±5.4 months of follow-up, no SLE flares occurred. None of the patients required glucocorticoid dose escalation or reduced the dose interval. Seven patients discontinued belimumab.
conclusionProgressive belimumab dose spacing and withdrawal, coupled with clinical monitoring, could be a practicable approach in selected patients with SLE with long-standing disease remission on minimal glucocorticoid doses, no additional immunosuppressants and low serological activity.
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