Evidence map›Paper›PMID 42425570›Full record

ArticleBMJ open2026

Effects of a fasting-mimicking diet on long-term prognosis in patients with colorectal cancer undergoing radical resection: protocol for a multicentre, prospective, randomised controlled trial.

Miaomiao Guo, Zhirong Sun, Ziwen Zhong, Hongli Hu, Yimin Qiu, Su Liu, Nadier Yimin, Chaoyang Tong, Fei Liang, Chunyan Ji and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05384444 (Effect of Perioperative Dietary Restriction Strategy on Postoperative Recovery and Outcomes of Patients With Colorectal Cancer), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05384444 naactive not recruitingnot on this map

Effect of Perioperative Dietary Restriction Strategy on Postoperative Recovery and Outcomes of Patients With Colorectal Cancer : a Multicenter Prospective, Randomized, Controlled Study

TypeinterventionalSponsorFudan UniversityRan2022 to 2027Enrolled602ConditionsFasting Mimicking Diet, Colorectal CancerArmsFasting mimicking diet
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Miaomiao GuoDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-1223-9257
Zhirong SunDepartment of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.
Ziwen ZhongDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Hongli HuFaculty of Anaesthesia, Changhai Hospital, Naval Medical University, Shanghai, China.
Yimin QiuDepartment of Anesthesiology, Shanghai General Hospital, Shanghai, China.
Su LiuDepartment of Anesthesiology, (Shanghai) Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Nadier YiminDepartment of Anesthesiology, Huashan Hospital Fudan University, Shanghai, China.
Chaoyang TongDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China.
Fei LiangDepartment of Biostatistics, Zhongshan Hospital Fudan University, Shanghai, China.
Chunyan JiDepartment of Clinical Nutrition, Zhongshan Hospital Fudan University, Shanghai, China.
Jianmin XuDepartment of Colorectal Surgery, Fudan University Zhongshan Hospital, Shanghai, China.
Xiaoming DengFaculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, China.
Changhong MiaoDepartment of Anesthesiology, Zhongshan Hospital Fudan University, Shanghai, China Miaochangh@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGiven the metabolic vulnerability of colorectal cancer (CRC) cells, periodic fasting-mimicking diets (FMDs) have emerged as a promising dietary strategy for improving clinical outcomes. Although preclinical studies have suggested that FMDs may suppress tumour growth and early-phase clinical trials have demonstrated their safety and feasibility, evidence regarding their effects on long-term survival outcomes in CRC remains limited because of certain constraints in patient cohorts and study designs. METHOD AND ANALYSIS: This multicentre, prospective, randomised controlled trial will be conducted at six tertiary comprehensive hospitals in China. It is anticipated that 602 eligible participants with clinical stage III CRC will be recruited. Participants will be randomly assigned at a 1:1 ratio to either the FMD group or the control group. After the 4-month dietary intervention, participants will continue to be followed up for 3 years. The primary outcome is 3-year disease-free survival. Participant enrolment began in June 2022, and the study is expected to be completed in December 2027. ETHICS AND DISSEMINATION: The study protocol was approved by the ethics committees of Zhongshan Hospital, Fudan University and other participating centres. The findings of this study will be disseminated through publication in peer-reviewed journals and presentation at academic conferences. TRIAL REGISTRATION NUMBER: NCT05384444.

Indexed as

Colorectal NeoplasmsDietFastingChinaDisease-Free SurvivalFemaleHumansIntermittent FastingMaleMulticenter Studies as TopicPrognosisProspective StudiesRandomized Controlled Trials as TopicColorectal surgeryFastingPrognosis

Identifiers

PMID42425570
PMCPMC13358252

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.