Observational studyThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Hospitalization for tuberculosis in children and adolescents: clinical, epidemiological characteristics and post-treatment sequelae at a referral center in Brazil.
Observational study in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis in children may require hospitalization and can be associated with the development of sequelae even after completion of antituberculosis treatment, with potential long-term impacts on the health of children and adolescents.
methodsThis observational, longitudinal study was based on the review of medical records of children and adolescents hospitalized for tuberculosis at a referral center in Brazil. Clinical and epidemiological characteristics, care pathways, and the occurrence of post-treatment sequelae were described. Bivariate and multivariable analyses were performed to identify factors associated with the development of sequelae.
resultsA total of 87 patients were included, predominantly of mixed race, of both sexes, with a median age of 6-years. After hospital discharge, 92.0% remained under follow-up at the referral center. Among these patients, 88.8% achieved a cure and 11.2% discontinued treatment. Among patients who were cured, 46.5% developed sequelae after treatment completion. The presence of sequelae was associated with age ≥ 10-years, pulmonary tuberculosis, and markers of greater disease severity during hospitalization, including the need for invasive mechanical ventilation and longer length of hospital stay.
conclusionsDespite the high cure rate, a substantial proportion of children and adolescents developed post-tuberculosis sequelae. These findings highlight the need for a comprehensive approach, including post-treatment and multidisciplinary follow-up, centered on children and adolescents, to reduce morbidity and long-term functional impairment across the life course.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.