Evidence map›Paper›PMID 42424771›Full record

ArticleEnvironment international2026

Epigenome-wide association analysis of prenatal organophosphate ester flame retardant exposure in maternal blood implicates maternal immune and neuronal epigenetic alterations.

Wanyi Tang, Helen Foley, Xiaoran Yang, Sahra Mohazzab-Hosseinian, Tingyu Yang, Ixel Hernandez-Castro, Kurunthachalam Kannan, Yijin Xiang, Huaiyu Mi, Joseph Wiemels and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Wanyi TangCenter for Genetic Epidemiology, Division of Epidemiology and Genetics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Helen FoleyDivision of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xiaoran YangDivision of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sahra Mohazzab-HosseinianDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Tingyu YangDivision of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ixel Hernandez-CastroDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Palo Alto, CA, USA.
Kurunthachalam KannanWadsworth Center, New York State Department of Health, Albany, NY 12237, USA.
Yijin XiangCenter for Genetic Epidemiology, Division of Epidemiology and Genetics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Huaiyu MiCenter for Genetic Epidemiology, Division of Epidemiology and Genetics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Joseph WiemelsCenter for Genetic Epidemiology, Division of Epidemiology and Genetics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Juan Pablo LewingerDivision of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Kimberly SiegmundDivision of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Theresa BastainDivision of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; School of Public Health, Washington University, St. Louis, MO, USA.
Carrie BretonDivision of Environmental Health, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; School of Public Health, Washington University, St. Louis, MO, USA. Electronic address: breton@wustl.edu.
Chang ShuCenter for Genetic Epidemiology, Division of Epidemiology and Genetics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: april.shu@usc.edu.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic LoadP50MD015705 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRETON, CARRIE VAN DOREN · 2020 to 2024
$8.1M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M · 2015 to 2019
$3.7M
Characterizing Autism Heterogeneity by Machine Learning Methods and Its Genetic and Environmental DriversR01MH143902 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Chang Shu · 2026 to 2026
$856k
EPA R836158NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P50 ES026086NIH HHS UH3 OD023287NIMHD NIH HHS P50 MD015705NIMH NIH HHS R01 MH143902
6 · The paper itself

Abstract

backgroundOrganophosphate esters (OPEs) are widely used flame retardants and plasticizers prevalent in indoor air, dust, and water. Studies suggest prenatal OPE exposure is linked to adverse maternal and infant outcomes, but the biological mechanisms remain unclear.

methodsWe examined associations between nine urinary OPE metabolites measured in the third trimester and DNA methylation in maternal blood from 175 pregnant women in the MADRES cohort. 837,856 CpGs were profiled using the Illumina EPIC array. We assessed the effect of each OPE (in tertile or detection status) and the joint effect of OPE mixtures using quantile g-computation models on DNA methylation sites, regions, and epigenetic age acceleration (EAA). Functional enrichment analyses were performed for suggestive CpGs and DMRs.

resultsWe identified cg09294299 (P = 2.33 × 10

conclusionsPrenatal OPE exposure is associated with altered maternal DNA methylation and epigenetic aging, highlighting immune, inflammatory, and neurodevelopmental pathways.

Indexed as

Epigenesis, GeneticEpigenomeFlame RetardantsMaternal ExposureOrganophosphatesAdultDNA MethylationEstersFemaleGenome-Wide Association StudyHumansPregnancyEstersFlame RetardantsOrganophosphates

Identifiers

PMID42424771
PMCPMC13588265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.