Improving Home Care Safety Among Informal Caregivers Through Immersive Digital Simulation: Secondary Analysis of 3 Coordinated Intervention Studies.

Background: Informal caregivers perform complex home-care tasks but often lack structured training, causing preventable safety risks and burden. Technology-enhanced simulation provides practice; psychoeducational programs that flag risky activities may strengthen safety behaviors and self-efficacy. Comparing costs guides scalable caregiver training. Objective: This study compared the cost-consequences of traditional and immersive digital simulation for home care, focusing on costs, errors avoided, and caregiver-burden reduction. Methods: This is a prospective observational comparative cohort study with secondary cost-consequence analysis and incremental cost-effectiveness ratios (ICERs) versus control, expressed in €/error avoided and €/burden point reduced. Costs are reported in euros. A prespecified synthesis of 3 coordinated studies yielded 3 active arms plus a control cohort, implemented independently between August 2023 and July 2025 under a shared core protocol in comparable Spanish home-care settings. Arms were psychoeducation, virtual reality (VR), 360° video training (360VT), and standard education as control. Outcomes were 3-month changes in self-reported errors and caregiver burden, measured with the Zarit Burden Interview-7 (ZBI-7; 0-28). Costing adopted a societal perspective and included staff time, caregiver time, and development costs amortized over 3 years at 200 participants/year. Downstream health care use was modeled by applying 1%-5% of follow-up incidents (base case 2%) to a €1,257 composite unit cost. Combined costs equaled direct plus downstream costs, with no discounting over 3 months. Costs and consequences were reported in natural units, including incremental and pairwise comparisons. Results: A total of 282 caregivers were included (psychoeducational n=71, VR n=70, 360VT n=71, and control n=70). Incident changes over a 3-month period were: +0.44 (95% CI 0.06 to 0.82) for control, -0.51 (95% CI -0.89 to -0.13) for psychoeducational, -0.56 (95% CI -0.97 to -0.20) for VR, and -0.20 (95% CI -0.66 to 0.09) for 360VT. Combined cost/per participant (direct +2% downstream) was: €46.88 for control, €77.04 for psychoeducational, €105.60 for VR, and €42.97 for 360VT. ICERs versus control were: (1) for errors avoided, -€31.75/error (95% CI €19.78 to -€54.98) for psychoeducation, €58.72/error (95% CI €39.40 to -€97.89) for VR, and 360VT was dominant, saving €6.11 (95% CI €4.24 to -€10.63) per error avoided, with €3.91 (95% CI €3.52 to -€4.29) saved per participant; (2) for burden reduced (ZBI-7), -€55.85/point (95% CI €38.27 to -€98.68) for psychoeducational, €45.88/point (95% CI €32.12 to -€76.67) for VR, and 360VT was dominant, saving €6.41 (95% CI €4.42 to -€11.23) per point reduced, with €3.91 (95% CI €3.52 to -€4.29) saved per participant. Pairwise for burden were as follows: (1) VR versus psychoeducational, €38.59 (95% CI €26.89 to -€66.13) per extra point; (2) 360VT versus psychoeducational dominant; and (3) VR versus 360VT, €93.48 (95% CI €64.41 to -€163.85) per extra point. Conclusions: This real-world cost-consequence analysis innovatively compares immersive and nonimmersive training for informal caregivers from a societal perspective, using harmonized safety, burden, and downstream cost outcomes. Findings support stepped adoption: 360VT as a scalable default, VR for higher-risk tasks or caregivers with greater burden, and psychoeducation as a complementary low-cost strategy when resources are constrained.