Evidence map›Paper›PMID 42424480›Full record

ArticleJBJS case connector2026

Daily Low-Dose Intra-Articular Povidone-Iodine Salvage of Refractory Fungal Total Knee Arthroplasty Infection: A Case Report.

Yutaka Fujita, Tomoharu Mochizuki, Shigeru Takagi, Keiichiro Someya, Hiroyuki Kawashima

Abstract readCase Reports
In one paragraph

Article in JBJS case connector, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yutaka FujitaDepartment of Orthopaedic Surgery, Niigata University Medical and Dental Hospital, Niigata, Japan.ORCID 0009-0005-2094-4804
Tomoharu MochizukiORCID 0000-0003-2565-0221
Keiichiro SomeyaORCID 0009-0000-7582-482
Hiroyuki KawashimaORCID 0000-0001-9511-9773

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

caseA 74-year-old woman developed refractory Candida parapsilosis periprosthetic joint infection (PJI) after total knee arthroplasty. Despite repeated debridement, implant removal, antifungal-loaded cement spacers, and prolonged systemic antifungal therapy, infection recurred and amputation was considered. Daily intra-articular low-dose povidone-iodine instillation achieved infection control without adverse events. After a 1-month drug holiday, hinged revision arthroplasty was performed. At 2 years, she ambulated independently without recurrence.

conclusionRepeated low-dose povidone-iodine instillation may be a salvage option for refractory fungal PJI.

Indexed as

Anti-Infective Agents, LocalArthroplasty, Replacement, KneeCandidiasisPovidone-IodineProsthesis-Related InfectionsSalvage TherapyAgedAntifungal AgentsCandida parapsilosisFemaleHumansAntifungal AgentsAnti-Infective Agents, LocalPovidone-IodineCandida parapsilosisdaily low-doseFungal periprosthetic joint infectionintra-articular instillationpovidone-iodinesalvage therapytotal knee arthroplasty

Identifiers

PMID42424480
PMCPMC13317899

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.