Evidence map›Paper›PMID 42424422›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

SpyCEP dismantles neutrophil immunity via disorder-driven chemokine remodeling and GAG targeting.

Rikin J Lau, Sean P Giblin, Andra Sugar, Antonio Di Maio, Giulio Tassini, Kristin Huse, Dror Chorev, Yuan Chen, Grace Ho-Yan Wu, Camilla Berg Huemer and 16 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Rikin J LauDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0009-0006-9304-0512
Sean P GiblinNational Heart and Lung Institute, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0001-9702-7987
Andra SugarDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Antonio Di MaioGlycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0002-2740-9098
Giulio TassiniGlaxoSmithKline Vaccines Institute for Global Health, Siena 53100, Italy.ORCID 0009-0009-3305-5394
Kristin HuseCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-8989-1863
Dror ChorevCTM Technologies and Materials Ltd., Ness-Ziona 7403626, Israel.ORCID 0000-0002-0751-0092
Yuan ChenGlycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.
Grace Ho-Yan WuDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Camilla Berg HuemerDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0009-0004-2383-5024
Seung Yon KimDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Jayden MatthewsDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Bel MuloudDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Lu ChenDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0009-0005-3444-3752
Sophie McKennaDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Yingqi XuDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.
Luisa MassaiGlaxoSmithKline Vaccines Institute for Global Health, Siena 53100, Italy.
Chiara MuzziGlaxoSmithKline Vaccines Institute for Global Health, Siena 53100, Italy.ORCID 0009-0002-2887-3180
Xhenti FerhatiGlaxoSmithKline Vaccines Institute for Global Health, Siena 53100, Italy.ORCID 0000-0002-4074-4499
Francesca NecchiGlaxoSmithKline Vaccines Institute for Global Health, Siena 53100, Italy.ORCID 0000-0003-1239-8696
Danilo Gomes MorielGlaxoSmithKline Vaccines Institute for Global Health, Siena 53100, Italy.
Ten FeiziGlycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0001-6495-0329
Yan LiuGlycosciences Laboratory, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0002-2566-6867
James E PeaseNational Heart and Lung Institute, Imperial College London, London W12 0NN, United Kingdom.ORCID 0000-0003-3749-0341
Shiranee SriskandanCentre for Bacterial Resistance Biology, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0002-5214-4941
Steve MatthewsDepartment of Life Sciences, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0003-0676-0927

Funding

UKRI | Medical Research Council (MRC) UKRI682Wellcome TrustWellcome Trust (WT) 215539/Z/19/Z
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bacterial ProteinsChemokinesGlycosaminoglycansInterleukin-8NeutrophilsStreptococcus pyogenesCryoelectron MicroscopyHumansBacterial ProteinsChemokinesCXCL8 protein, humanGlycosaminoglycansInterleukin-8cryo-EMCXCL8NMRSpyCEPStreptococcus pyogenes

Identifiers

PMID42424422
PMCPMC13367824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.