ArticleAngewandte Chemie (International ed. in English)2026
Hyperpolarization of Pyridine
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Magnetic resonance (MR) is a powerful non-invasive technique for probing structural, functional, and metabolic processes with high spatial and temporal resolution. However, its inherently low sensitivity restricts broader applications. The use of hyperpolarized contrast agents has thus, emerged as an attractive approach to overcome this limitation and expand the capabilities. Among the available hyperpolarization techniques, parahydrogen-induced polarization (PHIP) provides a rapid and cost-efficient means to enhance magnetic resonance signals substantially. Yet, direct hyperpolarization of biomolecules, metabolites, or pharmaceuticals in vivo remains challenging, necessitating the development of versatile molecular tags and probes for hyperpolarized magnetic resonance (HP-MR). In particular, imparting specific sensing functions-such as pH responsiveness and enzyme activity detection-to these HP molecular tags is of growing importance. Herein, we introduce pyridine N-oxides as hyperpolarizable molecular tags and present [
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