Evidence map›Paper›PMID 42424002›Full record

ArticleTropical animal health and production2026

Blood plasma proteome analysis reveals biological mechanisms and potential biomarkers underlying feed efficiency in Texel sheep.

Charleni Crisostomo Abdalla, Adibe Luiz Abdalla Filho, Ricardo Lopes Dias da Costa, Adibe Luiz Abdalla, Helder Louvandini, Daniela Lourenco, Claudia Cristina Paro de Paz, Nedenia Bonvino Stafuzza

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In one paragraph

Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charleni Crisostomo AbdallaCenter for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, Brazil.ORCID http://orcid.org/0000-0002-7267-5272
Adibe Luiz Abdalla FilhoCIISA / AL4AnimalS - Centre for Interdisciplinary Research in Animal Health, Associate Laboratory for Animal and Veterinary Science, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.ORCID http://orcid.org/0000-0001-5968-5380
Ricardo Lopes Dias da CostaResearch Center on Diversified Animal Husbandry, Animal Science Institute, São Paulo Agency of Agribusiness and Technology, Nova Odessa, Brazil.ORCID http://orcid.org/0000-0001-8888-6915
Adibe Luiz AbdallaCenter for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, Brazil.ORCID http://orcid.org/0000-0002-5440-9974
Helder LouvandiniCenter for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, Brazil.ORCID http://orcid.org/0000-0001-7129-8463
Daniela LourencoDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, 30602, USA.ORCID http://orcid.org/0000-0003-3140-1002
Claudia Cristina Paro de PazSustainable Livestock Research Center, Animal Science Institute, São José do Rio Preto, Brazil.ORCID http://orcid.org/0000-0002-7267-4552
Nedenia Bonvino StafuzzaDepartment of Animal and Dairy Science, University of Georgia, Athens, GA, 30602, USA. nedeniabs@gmail.com.ORCID http://orcid.org/0000-0001-6432-2330

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 444098/2024-0
6 · The paper itself

Abstract

Feed efficiency, usually assessed by residual feed intake (RFI) and residual intake and gain (RIG), is a key trait for enhancing the profitability and sustainability of livestock systems. Although several genes linked to feed efficiency have been identified, the molecular mechanisms underlying this trait are not well understood. This study identified potential biomarkers and molecular mechanisms for feed efficiency in Texel ewes using a proteome approach. Thirty-nine ewes were evaluated in a feedlot to calculate RFI and RIG. Blood samples of a subset of 12 animals at the extremes of the feed efficiency range (six low-efficiency and six high-efficiency) were used for proteomic analysis. Differentially abundant proteins between the groups (absolute fold change ≥ 2; p < 0.05) were used for protein-protein interaction (PPI) network analysis using the STRING tool and functional enrichment analysis using the DAVID tool. Proteomics analysis detected 2,580 proteins; of these, 35 were differentially abundant between the high- and low-efficiency groups. PPI analyses revealed proteins encoded by the AHSG, PLG, CP, AFM, KNG1, LTF, ITIH2, and ITIH3 genes to be important nodes based on their centrality and interactions. Functional enrichment analysis identified ferroptosis, iron transport, copper binding, phospholipid metabolism, ATP binding, and endopeptidase inhibitor activities as significant terms, which may potentially contribute to feed efficiency. The findings provide new insights into the molecular mechanisms underlying feed efficiency in sheep and contribute to identifying potential biomarkers that may support future genomic selection strategies aimed at improving the efficiency and sustainability of sheep production.

Indexed as

Blood ProteinsEatingProteomeSheep, DomesticAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsBiomarkersFemaleProteomicsSheepBiomarkersBlood ProteinsProteomeFunctional enrichment analysisLiquid chromatography–tandem mass spectrometryProtein-protein interactionResidual feed intakeResidual intake and gain

Identifiers

PMID42424002

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.