Biochemistry in 3D: A Virtual Reality Museum Approach to Molecular Learning.

Virtual reality (VR) is rapidly emerging as a powerful educational tool, transforming how students interact with complex scientific topics. This protocol details the use of FrameVR, a browser-based platform, to design an interactive virtual biochemistry museum focused on molecular topics such as protein conformation and ligand binding. Developed collaboratively with undergraduate students, the environment features 3D molecular models, embedded mini-lectures, and gamified assessment tools. This multisensory and immersive design aims to reinforce spatial understanding and cognitive engagement in biochemistry. By integrating pedagogical strategies such as scaffolding, guided exploration, and active learning, the VR space supports student autonomy and conceptual comprehension. Educators benefited from the platform's flexibility, enabling content to be presented in a visually engaging and evidence-based format. Student surveys suggest an improvement in topic understanding and retention, alongside increased engagement and motivation. VR holds immense potential to make abstract topics tangible and accessible, especially in STEM fields. As this medium becomes more widespread, thoughtful integration grounded in educational theory will be essential to ensure its impact is both meaningful and inclusive.