Evidence map›Paper›PMID 42423860›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Hangeshashinto for the prevention of oral mucositis in patients receiving chemotherapy: a systematic review and meta-analysis.

Mitsuru Ishizuka, Norisuke Shibuya, Hiroyuki Hachiya, Yusuke Nishi, Takahiro Kono, Masashi Takayanagi, Tetsutaro Nemoto, Keisuke Ihara, Takatoshi Nakamura, Tsunekazu Mizushima

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mitsuru IshizukaDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. mm-ishizuka@umin.ac.jp.ORCID http://orcid.org/0000-0003-3241-1480
Norisuke ShibuyaDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Hiroyuki HachiyaDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Yusuke NishiDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Takahiro KonoDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Masashi TakayanagiDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Tetsutaro NemotoDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Keisuke IharaDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Takatoshi NakamuraDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
Tsunekazu MizushimaDepartment of Colorectal Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAmong several adverse events induced by chemotherapy for patients with far advanced and unresectable cancer, oral mucositis is one that reduces patient quality of life.

objectiveTo evaluate the preventive effects of hangeshashinto on oral mucositis induced by chemotherapy.

methodsWe performed a comprehensive electronic literature search (PubMed, the Web of Science, and CENTRAL) up to March 2024 to identify studies showing the efficacy of hangeshashinto administration for preventing oral mucositis in patients receiving chemotherapy. To integrate the individual preventive effect of hangeshashinto, a meta-analysis was performed using random-effects models to calculate the risk ratio and 95% confidence interval, and heterogeneity was analyzed using I

resultsThis meta-analysis included six studies (five randomized controlled trials and one case-matched study) involving 293 patients with cancer receiving chemotherapy. Among 141 patients who received hangeshashinto during chemotherapy, 65 (46.1%) developed oral mucositis; in contrast, among 152 patients who did not receive hangeshashinto or received a placebo, 78 (51.3%) developed oral mucositis. The meta-analysis suggested that hangeshashinto may reduce the risk of oral mucositis (risk ratio = 0.86, 95% confidence interval = 0.73-1.00, P = 0.05, I

conclusionsThe results of this meta-analysis suggest that hangeshashinto may have a preventive effect against chemotherapy-induced oral mucositis. However, further well-designed randomized controlled trials are required to confirm its preventive efficacy.

Indexed as

Antineoplastic AgentsDrugs, Chinese HerbalStomatitisHumansNeoplasmsQuality of LifeRandomized Controlled Trials as TopicAntineoplastic AgentsDrugs, Chinese Herbalhange-shashintoChemotherapyHangeshashintoHerbal medicineMeta-analysisOral mucositis

Identifiers

PMID42423860
PMCPMC13350161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.