Evidence map›Paper›PMID 42423848›Full record

ArticleAging clinical and experimental research2026

Longitudinal associations of chronic pain and sleep quality with frailty progression in community-dwelling older adults.

Daijo Shiratsuchi, Hyuma Makizako, Shoma Akaida, Mana Tateishi, Yuto Kiuchi, Ryota Kuratsu, Takuro Kubozono, Toshihiro Takenaka, So Kuwahata, Mitsuru Ohishi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daijo ShiratsuchiDepartment of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.
Hyuma MakizakoDepartment of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan. makizako@health.nop.kagoshima-u.ac.jp.
Shoma AkaidaDepartment of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Mana TateishiDepartment of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Yuto KiuchiDepartment of Preventive Gerontology, Center for Gerontology and Social Science, Research Institute, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.
Ryota KuratsuGraduate School of Health Sciences, Kagoshima University, Kagoshima, Japan.
Takuro KubozonoDepartment of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Toshihiro TakenakaTarumizu Municipal Medical Center, Tarumizu Chuo Hospital, Kagoshima, Japan.
So KuwahataTarumizu Municipal Medical Center, Tarumizu Chuo Hospital, Kagoshima, Japan.
Mitsuru OhishiDepartment of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic pain is associated with frailty in older adults; however, the mechanisms underlying this relationship are not fully understood.

aimsTo examine whether sleep quality is involved in the longitudinal association between chronic pain and frailty progression in community-dwelling older adults.

methodsThis longitudinal study included 363 community-dwelling adults aged ≥ 65 years who participated in the 2018 and 2019 waves of the Tarumizu Study in Japan. Chronic pain was defined as self-reported lower back and/or knee pain lasting for at least 2 months. Sleep quality was assessed using a single-item questionnaire and categorized as good, medium, or poor. Frailty was assessed using the Kihon Checklist, and progression was defined as an increase ≥ 2 points over 1 year. Logistic regression and mediation analyses were conducted.

resultsFrailty progression was observed in 27.3% of participants. Chronic pain was significantly associated with frailty progression (odds ratio [OR]: 1.79; 95% confidence interval [CI]: 1.08-2.97), although this association was attenuated after adjustment for sleep quality. Poor sleep quality was independently associated with frailty progression (OR: 2.02; 95% CI: 1.04-3.91). Mediation analysis showed a significant indirect effect of chronic pain on frailty progression through sleep quality (β = 0.08; 95% CI: 0.001-0.20). DISCUSSION: Poor sleep quality may represent one potential pathway underlying the association between chronic pain and frailty progression in community-dwelling older adults.

conclusionsIntegrated assessment of pain and sleep problems may help identify older adults at greater risk of frailty progression.

Indexed as

Chronic PainFrailtySleep QualityAgedAged, 80 and overDisease ProgressionFemaleFrail ElderlyHumansIndependent LivingJapanLongitudinal StudiesMaleSurveys and QuestionnairesChronic painFrailtyMediation analysisSleep disturbance

Identifiers

PMID42423848
PMCPMC13633361

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.