ArticleHistochemistry and cell biology2026
Prenatal 3.5 GHz radiofrequency exposure induces renal histological changes and DNA damage in 6-month-old rats.
Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- July in focus in HCB: impact of environmental radiation on cells and tissues.Histochemistry and cell biology · 2026Article
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8 authors.
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Abstract
Early-life environmental stressors may influence long-term organ development and cellular homeostasis. This study investigated whether prenatal exposure to 3.5 GHz radiofrequency radiation (RFR) is associated with renal structural alterations, autophagy-related changes, and DNA damage in adult rat offspring. A total of 24 pregnant Wistar Hannover rats were randomly assigned to sham control, exposure during the last 2 weeks of gestation (D2T: exposure during the last 2 weeks of gestation), or exposure throughout gestation (D3T: exposure throughout gestation) groups (n = 8 dams per group). Male offspring were selected and euthanized at 6 months of age. Kidney tissues were examined histopathologically for structural alterations. Autophagy-related markers (Beclin-1 and LC3) were assessed by immunohistochemistry, and DNA damage was evaluated using the comet assay. Statistical analyses were performed using one-way analysis of variance (ANOVA) followed by appropriate post hoc tests. Peak spatial specific absorption rate (psSAR) values in the uterine region were 0.06622 mW/g (1 g averaging) and 0.03825 mW/g (10 g averaging). Prenatal RFR exposure was associated with significant renal histopathological alterations in offspring, most pronounced in the D3T group, including glomerular atrophy, tubular dilation, epithelial vacuolization, and cast formation (p < 0.01-0.001 versus controls). Beclin-1 and LC3 expression levels were significantly increased in both exposure groups (p < 0.001), suggesting altered autophagy-related marker expression. The comet assay demonstrated significantly increased DNA fragmentation in D2T and D3T groups compared with controls (p < 0.001), indicating increased genomic stress. Overall, prenatal exposure to 3.5 GHz RFR is associated with renal structural alterations, increased DNA damage, and changes in autophagy-related markers in adult rat offspring.
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