Evidence map›Paper›PMID 42423522›Full record

ArticleJournal of Alzheimer's disease : JAD2026

Low frequency blood-oxygen-level-dependent oscillations,

Trevor Lohman, Arunima Kapoor, Allison C Engstrom, Jillian Joyce, Melanie Quiring, John Paul M Alitin, Aimee Gaubert, Amy Nguyen, Elizabeth Head, Kathleen E Rodgers and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Trevor LohmanDepartment of Neurology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.ORCID 0000-0002-9634-702X
Arunima KapoorDepartment of Psychological Science, University of California, Irvine, CA, USA.ORCID 0000-0003-4622-8951
Allison C EngstromDepartment of Psychological Science, University of California, Irvine, CA, USA.
Jillian JoyceUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Melanie QuiringUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
John Paul M AlitinUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Aimee GaubertUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Amy NguyenUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Elizabeth HeadDepartment of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA.
Kathleen E RodgersCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
David BradfordCenter for Innovations in Brain Science, Department of Pharmacology, University of Arizona, Tucson, AZ, USA.
Basant LashinUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.ORCID 0000-0002-8979-7524
S Duke HanDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Mara MatherUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.
Daniel A NationUniversity of Southern California, Leonard Davis School of Gerontology, Los Angeles, CA, USA.ORCID 0000-0002-9123-0658

Funding

Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARTHUR W TOGA · 2016 to 2026
$28.4M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Elizabeth Head · 2020 to 2026
$27.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
Mid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's DiseaseK24AG081325 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUKE HAN · 2023 to 2026
$798k
NCATS NIH HHS KL2 TR001854NIA NIH HHS K24 AG081325NIA NIH HHS P01 AG052350NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228NIA NIH HHS R01 AG082073
6 · The paper itself

Abstract

BackgroundLow frequency oscillations in blood-oxygen-level-dependent signal (BOLD-LFOs) are generally considered nuisance signal in connectivity analysis and discarded. However, recent evidence suggests BOLD-LFOs shed light on cerebrovascular dysfunction and preclinical Alzheimer's disease, but the mechanisms remain unclear. No investigations have assessed the relationship between BOLD-LFOs and plasma pTau

Indexed as

Apolipoprotein E4BrainOxygentau ProteinsAgedFemaleHumansMagnetic Resonance ImagingMaleApolipoprotein E4MAPT protein, humanOxygentau ProteinsAlzheimer's diseaseAPOE4BOLD oscillationsneuroimaging biomarkerpTau217

Identifiers

PMID42423522
PMCPMC13499913

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.