ArticlePaediatric and perinatal epidemiology2026
Mortality Risk Between Ages 11 and 22 Years Among Young People With Neurodisability in England: A National Cohort Study Using Linked Health and Education Data.
Article in Paediatric and perinatal epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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7 authors.
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Abstract
backgroundMortality risk rises from childhood into early adulthood. Young people with neurodisability (neurological conditions causing functional limitations) may be particularly vulnerable during the transition from paediatric to adult services.
objectivesTo estimate all-cause and cause-specific mortality risk between the ages of 11-22 years in young people with and without neurodisability in England.
methodsIn this national cohort study, we used linked health and education records from ECHILD to follow pupils from age 11 between 2008-09 and 2014-15 to age 22. Neurodisability was identified from hospital admission records before age 11, likely capturing more severe conditions, and supplemented with education data for intellectual disability and autism. Gender-specific crude cumulative mortality risk and relative differences were estimated using Kaplan-Meier curves and Cox models, with cause-specific risk estimated using competing-risks methods.
resultsAmong 3,601,180 young people, 143,864 (4.0%) had neurodisability. Between the ages of 11-22, 5565 (0.15%) died; 24% had neurodisability. By age 22, cumulative mortality risk was 1.6% (95% confidence interval [CI] 1.4, 1.8) among females with neurodisability versus 0.14% (95% CI 0.13, 0.15) among peers without neurodisability (hazard ratio [HR] 13.88, 95% CI 12.55, 15.35), an absolute risk difference of 1.5% (95% CI 1.3, 1.6). Among males with neurodisability, cumulative risk was 1.3% (95% CI 1.2, 1.4) versus 0.28% (95% CI 0.27, 0.29; HR 5.34, 95% CI 4.94, 5.78) among peers, an absolute risk difference of 1.0% (95% CI 0.9, 1.1). Most deaths among those with neurodisability were from medical causes, with cumulative risks of 1.5% (95% CI 1.3, 1.6; HR 25.87, 95% CI 23.03, 29.07) in females and 1.1% (95% CI 0.96, 1.2; HR 14.70, 95% CI 13.29, 16.26) in males by age 22.
conclusionsYoung people with neurodisability had a higher mortality risk than peers between ages 11-22, largely from medical causes, with variation by gender and neurodisability subgroup.
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