ArticleInternational journal of rheumatic diseases2026
The Impact of Exercise Tolerance Assessed by 6-Min Walking Distance on Clinical Outcomes in Patients With Interstitial Lung Disease Associated With Connective Tissue Diseases.
Article in International journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to determine whether exercise tolerance assessed by 6-min walk distance (6MWD) predicts clinical outcomes in patients with connective tissue disease-associated interstitial lung disease (CTD-ILD).
methodsThis was an ambispective cohort study. We included patients in a stable condition with CTD-ILD. The 6MWD during hospitalization was used to determine the exercise tolerance. The primary endpoint was all-cause mortality, and the secondary endpoint was hospitalization for pulmonary disease. We examined the association between the 6MWD and each endpoint.
resultsAmong the 224 patients evaluated {median age 66.5 [interquartile range (IQR) 55.0-74.0] years; 146 females}, there were 23 deaths and 56 hospitalizations for pulmonary disease during the median follow-up period of 1.2 (IQR 0.6-2.3) years. The 6MWD of 310 m and 260 m were identified as optimal cut-off points for the prediction of all-cause mortality and hospitalization for pulmonary disease, respectively. The Kaplan-Meier survival curve showed that a higher 6MWD was associated with a lower rate of all-cause mortality and hospitalization for pulmonary disease (log-rank = 16.146, p < 0.001 and log-rank = 9.065, p = 0.003, respectively). After adjusting for clinical confounding factors, the hazard ratios for all-cause mortality and hospitalization for pulmonary disease per 10-m increase in 6MWD were 0.962 [95% confidence interval (CI): 0.927-0.998] and 0.968 (95% CI 0.946-0.991), respectively.
conclusionHigher exercise tolerance, as assessed by 6MWD, was independently associated with a better prognosis in stable patients with CTD-ILD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.