ArticleCNS neuroscience & therapeutics2026
Plasma Metabolomics of Thrombectomy-Treated Patients Highlights Metabolic Pathways Underlying Disease and Recovery.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
BACKGROUND AND
aimsThrombosis, characterized by pathological intravascular clot formation, underlies major clinical events such as cerebral infarction, myocardial infarction, and pulmonary embolism. However, metabolomic alterations associated with cerebral infarction, particularly those distinguishing patients with different clinical outcomes after recanalization, remain poorly characterized. This study aimed to provide an unbiased, systems-level characterization of metabolic alterations in cerebral infarction thrombosis.
methodsWe performed LC-MS/MS-based untargeted plasma metabolomics in both positive and negative ion modes. The cohort included 24 patients with meaningful functional recovery after cerebral infarction thrombectomy (MFR), 21 patients with futile recanalization (FTR), and 20 healthy controls (CON). Global metabolomic profiles were analyzed using multivariate and univariate approaches, followed by KEGG pathway enrichment analysis.
resultsPlasma metabolite profiles differed significantly among groups. Both MFR and FTR patients exhibited marked metabolic perturbations relative to controls, while the MFR group showed subtle but distinct metabolic patterns compared with FTR patients. Differential metabolites were enriched in pathways related to mitochondrial function, lipid signaling, amino acid metabolism, and inflammatory regulation, which are associated with endothelial function and thrombo-inflammatory responses in cerebral infarction.
conclusionThis study identifies metabolic alterations associated with cerebral infarction thrombosis and clinical outcome status following recanalization. These findings highlight candidate metabolites and pathways that may inform future mechanistic studies and biomarker validation specific to cerebral infarction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.