Evidence map›Paper›PMID 42423381›Full record

ArticleOrganic & biomolecular chemistry2026

Metacycloprodigiosin produced by a high-yield

Yaoyao Shen, Ansley M Nemeth, Roberta Melander, Christian Melander, Wei-Chen Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yaoyao ShenDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA. wchang6@ncsu.edu.ORCID http://orcid.org/0000-0002-1785-9001
Ansley M NemethDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA. cmelande@nd.edu.ORCID http://orcid.org/0000-0001-7249-5688
Roberta MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA. cmelande@nd.edu.
Christian MelanderDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA. cmelande@nd.edu.ORCID http://orcid.org/0000-0001-8271-4696
Wei-Chen ChangDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA. wchang6@ncsu.edu.ORCID http://orcid.org/0000-0002-2341-9846

Funding

Repurposing Gram-positive Antibiotics for Gram-Negative Bacteria using Antibiotic AdjuvantsR01AI167284 · NIAID · UNIVERSITY OF NOTRE DAME · PI MELANDER, CHRISTIAN COREY · 2022 to 2025
$3.7M
NIAID NIH HHS R01 AI167284
6 · The paper itself

Abstract

The prodiginine family constitutes a distinctive class of tripyrrolic natural products notable for their red pigmentation and diverse bioactivities. While the biological activities of the linear prodiginine prodigiosin have been extensively studied, cyclic prodiginines remain comparatively underexplored despite structural features that may confer distinct membrane-perturbing properties and enhanced antibacterial activity. Here, a high-producing colony variant of

Indexed as

Anti-Bacterial AgentsColistinDrug Resistance, BacterialGram-Negative BacteriaProdigiosinStreptomycesMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsColistinprodiginineProdigiosin

Identifiers

PMID42423381
PMCPMC13348189

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.