ReviewBioanalysis
Limited agreement of cytokines and CRP through patient-centric microsampling compared to venipuncture in healthy adults.
Review in Bioanalysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis low-interventional study assessed the agreement of the paper DBS and Tasso-M20, two dried blood patient-centric sampling (PCS) devices used to measure C-reactive protein (CRP) and cytokine levels (TNF-α, IL-8, IL-10, IL-2, IL-6, and IFN-γ) and compared the results to venous plasma samples in the general adult population. MATERIALS AND
methodsLevels of cytokines and CRP were measured with an assay for venous plasma, adapted for use with dried blood from PCS. Study participants also provided their preferences for blood sampling through a device usability questionnaire.
resultsCorrelations were observed for some of the selected cytokines measured with dried blood PCS devices compared to venous plasma. However, results were not always consistently and reliably measured. A subset of the cytokines could also not be detected in venous plasma. Overall, participants reported a preference for using PCS devices over venipuncture, on their own at home.
conclusionPCS shows promise for a better patient experience; however, our results highlight that further study of cytokines and CRP using PCS is needed before it can be used in place of venipuncture. Future studies should consider measurement of analytes in specific patient populations, whole blood matrix PCS, and potentially more sensitive assays.
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