ArticleClinical implant dentistry and related research2026
Long-Term Incidence of Peri-Implant Conditions: 25-Year Results of The Bernese Prospective Cohort Study.
Article in Clinical implant dentistry and related research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo assess 25-year implant survival, success rates, peri-implant conditions, and variables influencing peri-implant mucositis (PM), peri-implantitis (PI), and loss of osseointegration.
methodsPartially edentulous patients rehabilitated with tissue-level implant-supported prostheses were evaluated. Calibrated examiners performed clinical and radiographic assessments, and potential variables for PM and PI were analyzed at the final follow-up.
resultsAt the 10- and 25-year follow-ups, 303 and 159 patients with 511 and 252 implants, respectively, were included. Implant failure (IF) was 1.2% at 10 years and 6.0% at 25 years, with implant survival rates of 98.8% and 94.0%, respectively (p < 0.001). Implant success rates ranged from 97.0% at 10 years to 90.8% at 25 years (p < 0.001). IF due to loss of osseointegration increased from 0.6% to 3.6% at the implant level and from 1.0% to 2.5% at the patient level, and were located only in premolar or molar sites. At implant level, peri-implant health (PH) was 14.4% at 10 and 25 years (p = 1.00), while PM decreased from 82.1% to 76.5% (p = 0.08), and PI increased from 3.5% to 9.1% (p = 0.001). At patient level, PH remained stable between 10 and 25 years, ranging from 10.0% to 10.3% (p = 0.94), while PM decreased from 80.0% to 71.6% (p = 0.06), and PI increased from 10.0% to 18.1% (p = 0.01). In the multivariate analysis, history of periodontitis (OR = 3.87) and facial mucosal thickness (OR = 0.42) were associated with PM, whereas facial mucosal thickness was associated with PI (OR = 0.02).
conclusionsAfter 25 years, implant survival and success exceeded 90%. Loss of osseointegration accounted for approximately 60% of IF. While PI and IF increased over time, PM decreased but remained prevalent.
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