Evidence map›Paper›PMID 42423258›Full record

ArticleFEBS open bio2026

ATZ-1 promotes DNA replication efficiency to maintain normal meiotic function.

Taylin E Gourley, Luke W Molesworth, Nethma H Waduge, Fahimeh Eskandari, Peter R Boag, Gregory M Davis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Taylin E GourleyFederation University, Institute of Innovation, Science and Sustainability, Australia.
Luke W MolesworthFederation University, Institute of Innovation, Science and Sustainability, Australia.
Nethma H WadugeDepartment of Biomedical, Health and Exercise Sciences, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Fahimeh EskandariDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
Peter R BoagDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
Gregory M DavisFederation University, Institute of Innovation, Science and Sustainability, Australia.ORCID https://orcid.org/0000-0002-9308-9790

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise coordination of DNA replication and meiotic progression is essential for germline genome stability, yet a complete understanding of this interplay remains unknown. In this study, we show that the absence of Abnormal Transition Zone 1 (atz-1) in Caenorhabditis elegans results in abnormal germline architecture and oocyte development. Specifically, atz-1 mutants display depleted S-phase DNA replication and acute sensitivity to depletion of the checkpoint kinase 1 (chk-1), but not chk-2. These findings suggest that ATZ-1 promotes replication efficiency during premeiotic S-phase, potentially suppressing replication stress and enabling timely meiotic progression. Collectively, this work demonstrates that ATZ-1 contributes to germline genome integrity by influencing cell cycle processes, which, if disrupted, result in numerous downstream germline defects.

Indexed as

cell cycleDNA replicationgerm cellsmeiosismitosisoogenesis

Identifiers

PMID42423258
PMCPMC13398775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.