Evidence map›Paper›PMID 42423229›Full record

ArticleTherapeutic advances in respiratory disease

Inflammatory activity as a predictor of clinical deterioration in interstitial pneumonia with autoimmune features: a comparative cohort study with connective tissue disease-associated interstitial lung disease.

Firdevs Ulutaş, Nilüfer Yiğit, Gülay Güngör, Veli Çobankara

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Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Firdevs UlutaşDivision of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Pamukkale, Denizli 20160, Türkiye.ORCID 0000-0001-8441-5219
Nilüfer YiğitDepartment of Chest Diseases and Pulmonology, Pamukkale University Faculty of Medicine, Pamukkale, Denizli, Türkiye.ORCID 0000-0002-5871-6461
Gülay GüngörDepartment of Radiology, Pamukkale University Faculty of Medicine, Pamukkale, Denizli, Türkiye.
Veli ÇobankaraDivision of Rheumatology, Department of Internal Medicine, Pamukkale University Faculty of Medicine, Pamukkale, Denizli, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterstitial pneumonia with autoimmune features (IPAF) represents a heterogeneous entity overlapping with connective tissue disease-associated interstitial lung disease (CTD-ILD); however, its clinical course and prognostic determinants remain incompletely characterized.

objectiveThis study aimed to compare baseline characteristics, outcomes, and predictors of poor prognosis between IPAF and CTD-ILD, and to evaluate the prognostic performance of selected inflammatory indices.

designThis study was designed as a single-center, retrospective cohort analysis evaluating clinical characteristics, radiological features, and prognostic outcomes in patients with interstitial lung disease.

methodsThis retrospective cohort study included 88 patients with ILD, categorized as IPAF (

resultsPatients with IPAF were older at diagnosis compared with CTD-ILD (median 68.5 vs 56.0 years,

conclusionAlthough IPAF and CTD-ILD differ in baseline phenotype, their clinical trajectories appear similar. Persistent systemic inflammation, reflected by sustained ESR elevation, independently predicts adverse outcomes, while commonly used prognostic scores demonstrate limited utility.

Indexed as

Autoimmune DiseasesConnective Tissue DiseasesInflammationLung Diseases, InterstitialAdultAgedCohort StudiesDisease ProgressionFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesVital CapacityCTD-ILDderived neutrophil-to-lymphocyte ratioerythrocyte sedimentation rateGAP scoreIPAFlung immune prognostic indexprogressive pulmonary fibrosis

Identifiers

PMID42423229
PMCPMC13351220

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