Direct Regioselective para-Fluorination via I(I)/I(III) Catalysis.

Christoph Roblick, Julian D Bendix, Timothy A Hilton, Kathrin Bussmann, Constantin G Daniliuc, Ryan Gilmour

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christoph RoblickInstitute for Organic Chemistry, University of Münster, Münster, Germany.

Julian D BendixInstitute for Organic Chemistry, University of Münster, Münster, Germany.

Timothy A HiltonInstitute for Organic Chemistry, University of Münster, Münster, Germany.

Kathrin BussmannInstitute for Organic Chemistry, University of Münster, Münster, Germany.

Constantin G DaniliucInstitute for Organic Chemistry, University of Münster, Münster, Germany.

Ryan GilmourInstitute for Organic Chemistry, University of Münster, Münster, Germany.ORCID https://orcid.org/0000-0002-3153-6065

Funding

Deutsche Forschungsgemeinschaft GRK2678-437785492University of Münster, the European Research Council 101157249

6 · The paper itself

Abstract

Fluorine scanning is an expansive strategy to refine the physicochemical profile of clinically important small molecule drugs. Of the possible regioisomers derived from mono-substituted benzenes, the para-fluorophenyl motif has emerged as a conspicuous chemotype: Lipitor is a compelling exemplar. When considered through this molecular design lens, the development of effective routes to generate this privileged module, without substrate pre-functionalization, remains very much in focus. Herein, we report a direct, para-selective fluorination that operates under the auspices of I(I)/I(III) catalysis. This enabling strategy leverages the venerable Leonard link inherent to phenylpropanoate and phenylpropanamides to promote a spirocyclization/para-selective activation sequence. Aside from biasing regioselectivity, the C

Indexed as

catalysisfluorinationhypervalent iodineorganocatalysisregioselectivity

Identifiers

PMID42423227

DOI10.1002/anie.5570530

PMCPMC13548900

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.