Observational studyCardiovascular research2026
Atrial fibrillation in patients with left ventricular non-compaction: incidence and associations with stroke, heart failure, and mortality.
Observational study in Cardiovascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Long-Term Outcomes in Patients with Dilated Left Ventricular Non-Compaction Versus Dilated Cardiomyopathy: A Propensity Score Matching Study.Journal of cardiovascular development and disease · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsLeft ventricular non-compaction (LVNC) is a genetic cardiomyopathy with presentations ranging from asymptomatic disease to heart failure, stroke, and sudden cardiac death. LVNC-related structural and functional abnormalities may increase atrial fibrillation (AF) risk, but data are limited. We assessed AF incidence in LVNC and compared outcomes in patients with vs. without AF. METHODS AND
resultsTwo cohorts of patients were identified using the TriNetX platform: (i) patients with LVNC without a prior history of AF and (ii) patients with LVNC and AF. The primary objective was to assess the 3 year risk of a composite of all-cause mortality, stroke, acute myocardial infarction, and heart failure in the two cohorts. Hazard ratios (HRs) were derived from univariable Cox proportional models before and after propensity score matching (PSM). Matching was conducted using a greedy nearest-neighbour approach with a calliper of 0.1. Patients with LVNC and AF (N = 29 356) were older and exhibited a higher burden of comorbidities compared with LVNC patients without AF (N = 39 339). In this observational analysis, after PSM, AF in patients with LVNC was associated with higher risks of stroke [HR 1.466, 95% confidence interval (CI) 1.359-1.581], new-onset heart failure (HR 1.439, 95% CI 1.358-1.526), all-cause death (HR 1.255, 95% CI 1.200-1.312), and the composite outcome (HR 1.301, 95% CI 1.269-1.334) compared with LVNC patients without AF. The 1 year incidence of AF in patients with LVNC was 36 per 1000 person-years.
conclusionIn this observational cohort, LVNC was associated with a high incidence of AF, and the presence of AF was associated with higher risks of stroke, heart failure, and all-cause death. Further prospective studies are warranted to assess the prognostic impact of AF in patients with LVNC.
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