Evidence map›Paper›PMID 42423157›Full record

ArticleAging cell2026

Proteostasis Rebalancing by LET-607 Deficiency Promotes Longevity.

Haixiang Tong, Wei Li, Pangui Yuan, Feng Li, Qin Liu, Shanshan Pang, Haiqing Tang

Abstract read
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haixiang TongSchool of Life Sciences, Chongqing University, Chongqing, China.
Wei LiSchool of Life Sciences, Chongqing University, Chongqing, China.
Pangui YuanSchool of Life Sciences, Chongqing University, Chongqing, China.
Feng LiSchool of Life Sciences, Chongqing University, Chongqing, China.
Qin LiuSchool of Life Sciences, Chongqing University, Chongqing, China.
Shanshan PangSchool of Life Sciences, Chongqing University, Chongqing, China.ORCID https://orcid.org/0000-0002-7872-1524
Haiqing TangSchool of Life Sciences, Chongqing University, Chongqing, China.ORCID https://orcid.org/0000-0003-0604-2765

Funding

National Natural Science Foundation of China 32370828National Natural Science Foundation of China 32571349
6 · The paper itself

Abstract

Disruption of proteostasis is a hallmark of aging. Given that cellular resources are limited, this necessitates a coordinated orchestration of different proteostatic subsystems. Yet, the principles governing this process, including the potential role of trade-offs, are not well defined. Here, we report a trade-off between the endoplasmic reticulum unfolded protein response (UPR

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsLongevityProteostasisAnimalsUnfolded Protein ResponseCaenorhabditis elegans ProteinsHSF‐1longevityproteostasisunfolded protein response

Identifiers

PMID42423157
PMCPMC13347320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.