ArticleAdvanced functional materials2021
A Flexible and Regenerative Aptameric Graphene-Nafion Biosensor for Cytokine Storm Biomarker Monitoring in Undiluted Biofluids toward Wearable Applications.
Article in Advanced functional materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- Passive, Electromagnetic-Responsive Hydrogel Immunosensor for Exercise Intensity Monitoring Based on Sweat C-Reactive Protein.Advanced healthcare materials · 2026Article
- Optimizing Surface Functionalization for Aptameric Graphene Nanosensors in Undiluted Physiological Media.Sensors (Basel, Switzerland) · 2026Article
- Advancement in continuous lactate determination in untreated human serum: multipolymer-based amperometric biosensor coupled with a low-cost 3D-printed microfluidic cell.Mikrochimica acta · 2025Article
- A Review of Graphene-Integrated Biosensors for Non-Invasive Biochemical Monitoring in Health Applications.Sensors (Basel, Switzerland) · 2025Review
- Noninvasive On-Skin Biosensors for Monitoring Diabetes Mellitus.Nano-micro letters · 2025Review
- Review
- Nafion in Biomedicine and Healthcare.Polymers · 2025Review
- Graphene-based wearable biosensors for point-of-care diagnostics: From surface functionalization to biomarker detection.Materials today. Bio · 2025Review
- Review
- Integration Strategies and Formats in Field-Effect Transistor Chemo- and Biosensors: A Critical Review.ACS sensors · 2025Review
- Article
- Recent Progress of Polymer-Based Biosensors for Cancer Diagnostic Applications: Natural versus Synthetic Polymers.ACS omega · 2025Review
- Wearable Biodevices Based on Two-Dimensional Materials: From Flexible Sensors to Smart Integrated Systems.Nano-micro letters · 2025Review
- Human Serum Albumin-CoatedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Flexible Graphene Field-Effect Transistors and Their Application in Flexible Biomedical Sensing.Nano-micro letters · 2024Review
- 2D Materials in Advanced Electronic Biosensors for Point-of-Care Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Nucleic acid-based wearable and implantable electrochemical sensors.Chemical Society reviews · 2024Review
- Gamma radiation assisted green synthesis of hesperidin-reduced graphene oxide nanocomposite targeted JNK/SMAD4/MMP2 signaling pathway.Scientific reports · 2024Article
- Advancements in Airborne Viral Nucleic Acid Detection with Wearable Devices.Advanced sensor research · 2024Article
- Nanotechnology in inflammation: cutting-edge advances in diagnostics, therapeutics and theranostics.Theranostics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Wearable sensors that can conveniently detect cytokine levels in human biofluids are essential for assisting hospitals to maximize the benefits of anti-inflammatory therapies and avoid cytokine storm with high mortality. Measurement of cytokine levels in biofluids still remains challenging for existing sensors due to high interferences from the background. Here, this challenge is overcome through developing a flexible and regenerative aptameric field-effect transistor biosensor, consisting of a graphene-Nafion composite film, for detecting cytokine storm biomarkers in undiluted human biofluids. The composite film enables the minimization of nonspecific adsorption and empowers the renewability to the biosensor. With these capabilities, the device is capable of consistently and sensitively monitoring cytokines (e.g., IFN-γ, an inflammatory and cancer biomarker) in undiluted human sweat with a detection range from 0.015 to 250 nM and limit of detection down to 740 fM. The biosensor is also shown to incur no visible mechanical damages and maintian consistent sensing response throughout the regenerative (up to 80 cycles) and crumpling (up to 100 cycles) tests. Experimental results demonstrate that the biosensor is expected to offer opportunities for developing wearable biosensing systems for distinguishing acute infectious disease patients and monitoring of patients' health conditions in daily life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.