ReviewFrontiers in medicine2026
Positive end-expiratory pressure titration in acute respiratory distress syndrome-a practical bedside algorithm.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Positive end-expiratory pressure (PEEP) selection and titration is a longstanding debate in management of mechanically ventilated patients with acute respiratory distress syndrome (ARDS). Although multiple strategies have been tested, heterogeneity in ARDS physiology, co-interventions, and variable recruitability have limited clear conclusions. Advanced monitoring may support individualized titration, but availability and outcome evidence remain limited. In this article we present a narrative review of the evidence behind different PEEP setting strategies and propose a practical bedside algorithm in 5 steps to individualize PEEP settings. It incorporates guideline-protective ventilation, assessment of recruitability, prone position and consideration of rescue therapies. The proposed algorithm is guided by physiology and readily available ventilator-derived parameters, intended to be used by any clinician at the bedside.
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