SynthesisFrontiers in medicine2026
Effectiveness of strength-oriented rehabilitation interventions as a non-pharmacologic rehabilitation strategy for knee function after anterior cruciate ligament reconstruction: a three-level meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Persistent deficits in periarticular muscle strength and functional performance are commonly observed following anterior cruciate ligament reconstruction, potentially compromising long-term knee joint health. As a key non-pharmacologic rehabilitation strategy, strengthening exercise is widely implemented to address these impairments. However, evidence regarding its effects on knee muscle strength and hop-performance outcomes remains inconsistent. Therefore, this study aimed to systematically quantify the effects of strengthening exercise on knee muscle strength and hop performance after ACLR using a three-level meta-analytic approach. Methods: PubMed, Web of Science, Embase, Cochrane Library, and SPORTDiscus were searched through January 6, 2026. Randomized controlled trials examining strengthening-based rehabilitation after ACLR were included. Standardized mean differences (Hedges' g) were calculated from pre-post change scores. Three-level multivariate random-effects meta-analyses were conducted, with moderator analyses examining postoperative time, population type, and assessment time point. Risk of bias was assessed using RoB 2, and publication bias was explored via funnel plots and Egger's regression. Results: Nine trials were included, contributing a total of 24 effect sizes across outcomes. Strengthening exercise significantly improved knee muscle strength ( Conclusion: Strength-oriented rehabilitation interventions appear to improve knee muscle strength following ACL reconstruction, whereas no significant overall effect was observed for hop performance. Comprehensive rehabilitation strategies addressing neuromuscular and functional demands may be required to optimize postoperative recovery.
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