Evidence map›Paper›PMID 42422826›Full record

ArticleFrontiers in medicine2026

Clinical and prognostic differences in mild to moderate AECOPD with and without emphysema: a 3-year multicenter prospective study.

Jiaqi Pu, Mingjing Yu, Hailong Wei, Huiqing Ge, Huiguo Liu, Jianchu Zhang, Pinhua Pan, XiuFang Xie, Mengqiu Yi, Xianhua Li and 7 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Jiaqi Pu *Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Mingjing Yu *Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Hailong WeiDepartment of Respiratory and Critical Care Medicine, People's Hospital of Leshan, Leshan, Sichuan, China.
Huiqing GeDepartment of Respiratory and Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Huiguo LiuDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jianchu ZhangDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Pinhua PanDepartment of Respiratory and Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China.
XiuFang XieDepartment of Respiratory and Critical Care Medicine, The First People's Hospital of Neijiang City, Neijiang, Sichuan, China.
Mengqiu YiDepartment of Emergency, First People's Hospital of Jiujiang, Jiujiang, Jiangxi, China.
Xianhua LiDepartment of Respiratory and Critical Care Medicine, The First People's Hospital of Neijiang City, Neijiang, Sichuan, China.
Lina ChengDepartment of Emergency, First People's Hospital of Jiujiang, Jiujiang, Jiangxi, China.
Hui ZhouDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Jiarui ZhangDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiaxin ZengDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Xueqing ChenDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Haixia ZhouDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qun YiDepartment of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The prognostic significance of the computed tomography (CT)-defined emphysema phenotype in patients hospitalized with mild-to-moderate acute exacerbation of chronic obstructive pulmonary disease (AECOPD) remains poorly defined. Materials and methods: This prospective multicenter cohort study analyzed data from the MAGNET AECOPD Registry. We included patients hospitalized with mild-to-moderate AECOPD (Rome criteria) who underwent chest CT within 24 h of admission. Participants were categorized into emphysema and non-emphysema groups based on visual CT assessment. The primary outcome was 3-year all-cause mortality; secondary outcomes included rehospitalization and in-hospital events. Propensity score matching balanced baseline characteristics. Results: Among 5,713 eligible patients, 4,558 (79.8%) had emphysema. After 1:1 propensity score matching ( Conclusion: In mild-to-moderate AECOPD, the emphysema phenotype predicts higher acute morbidity yet lower long-term mortality. This finding suggests potential distinct pathophysiological pathways and supports further investigation of CT-based phenotyping for personalized management in COPD. Clinical trial registration: http://www.chictr.org.cn/showproj.aspx?proj=121626, Identifier ChiCTR2100044625.

Indexed as

computed tomographyCOPD exacerbationemphysema phenotypemortalityprognosis

Identifiers

PMID42422826
PMCPMC13341661

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