Evaluation of extracorporeal membrane oxygenation in children with acute hypoxemic respiratory failure and hemodynamic instability in China: a 7-year single-center retrospective study.

Jiayun Ying, Xiaodi Cai, Gangfeng Yan, Ye Cheng, Weiming Chen, Guoping Lu

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Jiayun Ying *Department of Critical Care Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Xiaodi Cai *Department of Critical Care Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Gangfeng YanDepartment of Critical Care Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Ye ChengDepartment of Critical Care Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Weiming ChenDepartment of Critical Care Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Guoping LuDepartment of Critical Care Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To characterize the clinical features, laboratory parameters, and outcomes of pediatric patients with acute hypoxemic respiratory failure (AHRF) and concurrent hemodynamic instability requiring extracorporeal membrane oxygenation (ECMO), and to identify risk factors associated with mortality. Methods: This retrospective study was conducted in the Pediatric Intensive Care Unit (PICU) of the Children's Hospital of Fudan University, China. We enrolled patients aged 28 days-18 years with AHRF and hemodynamic instability despite mechanical ventilation who received ECMO support between January 2015 and December 2021. The primary outcome was 28-day in-hospital mortality. Data including demographics, comorbidities, laboratory findings, ventilator settings, and rescue therapies were analyzed. Multivariable logistic regression analysis was used to identify independent risk factors for survival. Receiver operating characteristic (ROC) curves and Kaplan-Meier survival curves were subsequently constructed to evaluate the predictive performance and compare cumulative survival rates, respectively. Results: Out of 57 eligible patients, 52 (91.2%) were included in the final analysis. The overall mortality rate was 53.8%. Successful weaning, achieved in 34 patients, correlated strongly with improved survival ( Conclusion: For pediatric patients with severe AHRF and hemodynamic compromise placed on VA-ECMO, lower pre-ECMO PaO

Indexed as

acute hypoxemic respiratory failureextracorporeal membrane oxygenationhemodynamic instabilitypediatric intensive care unitP/F ratio

Identifiers

PMID42422825

DOI10.3389/fmed.2026.1867681

PMCPMC13341832

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