ArticleNational journal of maxillofacial surgery
Transforming growth factor alpha polymorphism and cleft lip and palate in North Indian Population.
Article in National journal of maxillofacial surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: One of the most common congenital malformations, with widespread racial and regional variation, is an orofacial cleft. Cleft lip and palate (CLP) are a congenital anomaly that results in incomplete or non-fusion of the lip and/or palate during the embryonic development of the child. Many studies support that the occurrence of CLP is attributed to a combination of factors of environment and genes. Earlier studies had studied many candidate genes for CLP in different populations but not all are significant to every population. Transforming growth factor alpha ( Aim and Objectives: In this study, we studied the Methods: An observational case-control study was conducted on 50 patients presenting with oral clefts in hospitals, who were categorized as Cases and 50 controls were selected that were free from any defect. Controls were coming to the hospital for some other type of treatment. Cases were evaluated for various phenotypes of clefts. Blood samples of each case and control were collected to extract genomic deoxyribonucleic acid (DNA) and to further analyze the Results: The results for gene polymorphism showed a significant association between Conclusion: If we can identify any trait beforehand that is somehow linked with cleft lip and palate, we can help parents and children. This study provides evidence for an association between
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