ReviewNational journal of maxillofacial surgery
Systematic review on utility of stem-cell engineering on outcome of oral and maxillofacial prosthesis (rehabilitation).
Review in National journal of maxillofacial surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral and maxillofacial (OMF) defects present complex clinical challenges, often requiring advanced reconstructive techniques. Stem-cell-based tissue engineering, particularly using mesenchymal stem cells (MSCs), has emerged as a promising alternative for OMF rehabilitation, offering the potential for tissue regeneration and modulation of healing responses. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science databases to identify relevant studies published between 2014 and 2024. Studies included focused on the application of stem cells, scaffolds, and biomaterials in the regeneration of OMF tissues. Eligibility criteria included clinical trials, observational studies, reviews, and case series involving human, animal, or in vitro models related to OMF defects. A total of 10 studies met the inclusion criteria, encompassing a range of methodologies and stem cell types, such as dental MSCs, adipose-derived stem cells (ADMSCs), and bone marrow stem cells (BMSCs). Key findings indicate that MSCs, when combined with advanced biomaterials and scaffold technologies, significantly enhance tissue regeneration and functional restoration in OMF reconstruction. However, challenges such as achieving vascularization and long-term viability of engineered tissues, as well as standardization of treatment protocols, remain significant barriers to clinical translation. Stem-cell-based therapies exhibit substantial potential for improving outcomes in OMF reconstruction. Despite promising advancements, further research is necessary to overcome limitations related to tissue integration, clinical translation, and ethical considerations. Optimizing these therapies is crucial for their effective and safe implementation in clinical settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.