ArticleResearch and practice in thrombosis and haemostasis2026
Differential expression of miR-128 in memory T cells of patients with severe hemophilia A with and without inhibitors.
Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Inhibitor development occurs in ∼30% of persons with severe hemophilia A treated with factor (F)VIII replacement products, but the real mechanism of the development is poorly known. miR-128 is a crucial regulator of immune responses, and it is implicated in the pathobiology of various autoimmune disorders. Objectives: To investigate the expression of miR-128 in peripheral blood mononuclear cells (PBMCs) and CD4 Methods: Forty-five patients with severe hemophilia A, >50 exposures to FVIII and with persistent ( Results: A statistically significant increase in miR-128 levels in PBMCs (1.5-fold change; Conclusion: The present study indicates an overexpression of miR-128 in memory T cells of persons with severe hemophilia A developing inhibitors, likely regulating the expression of key genes in T cell differentiation.
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